{{Rsnum
|rsid=2511989
|Gene=SERPING1
|Chromosome=11
|position=57610852
|Orientation=minus
|GMAF=0.3228
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SERPING1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 22.1 | 40.7 | 37.2
| HCB | 0.7 | 19.0 | 80.3
| JPT | 4.4 | 26.5 | 69.0
| YRI | 11.6 | 51.0 | 37.4
| ASW | 17.5 | 43.9 | 38.6
| CHB | 0.7 | 19.0 | 80.3
| CHD | 1.8 | 17.4 | 80.7
| GIH | 21.8 | 52.5 | 25.7
| LWK | 22.7 | 47.3 | 30.0
| MEX | 10.3 | 34.5 | 55.2
| MKK | 17.4 | 42.6 | 40.0
| TSI | 15.7 | 46.1 | 38.2
| HapMapRevision=28
}}{{PMID|18842294}} [http://www.medpagetoday.com/Ophthalmology/GeneralOphthalmology/tb/11203 news] 

{{PMID|19169411|OA=1
}} [[rs2511989]] not associated with AMD  

[[rs2511989]](A;A) had a protective effect against [[age related macular degeneration]].

Comparison of the [[rs2511989]](A;G) genotype and the wild type (G;G) genotype yielded an odds ratio of 0.63 (CI: 0.47 to 0.84) for age-related macular degeneration.

Comparison of [[rs2511989]](A;A) homozygotes with (G;G) homozygotes resulted in an odds ratio of 0.44 (CI: 0.31 to 0.64).

{{PMID Auto
|PMID=19607829
|Title=Localization of Complement 1 Inhibitor (C1INH/SERPING1) in Human Eyes with Age-Related Macular Degeneration
|OA=1
}}

{{PharmGKB
|RSID=rs2511989
|Name_s=
|Gene_s=SERPING1
|Feature=
|Evidence=PubMed ID:18842294
|Annotation=A case-control study in a UK sample of 479 patients with age-related macular degeneration and 479 controls identified a highly significant association of this variant in intron six of the SERPING1 gene with age-related macular degeneration.
|Drugs=
|Drug Classes=
|Diseases=Macular Degeneration
|Curation Level=Curated
|PharmGKB Accession ID=PA162355780
}}

{{PMID Auto
|PMID=20161815
|Title=SERPING1 polymorphisms in polypoidal choroidal vasculopathy
|OA=1
}}

{{PMID Auto
|PMID=20062564
|Title=An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population
|OA=1
}}

{{PMID Auto
|PMID=20576771
|Title=Determination of a gene and environment risk model for age-related macular degeneration
}}
{{PMID Auto
|PMID=20606025
|Title=The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration
|OA=1
}}

{{PharmGKB
|RSID=rs2511989
|Name_s=
|Gene_s=SERPING1
|Feature=
|Evidence=PubMed ID:18842294
|Annotation=This variant is located within intron six of the SERPING1 gene and strongly associated with age-related macular degeneration.
|Drugs=
|Drug Classes=
|Diseases=Macular Degeneration
|Curation Level=Curated
|PharmGKB Accession ID=PA162356022
}}

{{PMID Auto
|PMID=19026761
|Title=Molecular pathology of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=21609242
|Title=Age-related macular degeneration-susceptibility single nucleotide polymorphisms in a han chinese control population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2511989
|overall_frequency_n=56
|overall_frequency_d=128
|overall_frequency=0.4375
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}