{{Rsnum
|rsid=2518224
|Gene=GRIK2
|Chromosome=6
|position=101458776
|Orientation=plus
|GMAF=0.06933
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=GRIK2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 72.6 | 26.5 | 0.9
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 95.2 | 4.8 | 0.0
| ASW | 96.5 | 3.5 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 94.1 | 5.9 | 0.0
| LWK | 95.5 | 4.5 | 0.0
| MEX | 82.8 | 15.5 | 1.7
| MKK | 85.9 | 14.1 | 0.0
| TSI | 83.2 | 13.9 | 3.0
| HapMapRevision=28
}}This SNP, located in an intron of the [[GRIK2]] gene, has been linked in one study to increased thoughts of [[suicide]] in patients using the anti-depressant drug [[citalopram]]. The risk is only seen for individuals carrying two [[rs2518224(C)]] alleles, i.e. the [[rs2518224(C;C)]] homozygotes. The odds ratio for these individuals is 8.2. If the individual also has at least one [[rs4825476(G)]] allele, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). {{PMID|17898344}}

{{PharmGKB
|RSID=rs2518224
|Name_s=
|Gene_s=GRIK2
|Feature=
|Evidence=PubMed ID:17898344
|Annotation=This SNP in the GRIK2 gene was associated with treatment-emergent suicidal ideation during citalopram therapy in a clinically representative cohort of outpatients with major depressive disorder. DNA samples from 1,915 participants were genotyped.
|Drugs=citalopram
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162263539
}}

{{PMID Auto
|PMID=19724244
|Title=Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.
|OA=1
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2518224
|overall_frequency_n=9
|overall_frequency_d=128
|overall_frequency=0.0703125
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}