{{Rsnum
|rsid=2522833
|Gene=PCLO
|Chromosome=7
|position=82824392
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=G
|GMAF=0.4242
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=PCLO
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 34.8 | 50.9 | 14.3
| HCB | 8.9 | 38.5 | 52.6
| JPT | 15.6 | 42.2 | 42.2
| YRI | 93.1 | 6.9 | 0.0
| ASW | 82.5 | 17.5 | 0.0
| CHB | 8.9 | 38.5 | 52.6
| CHD | 4.7 | 42.1 | 53.3
| GIH | 24.0 | 43.0 | 33.0
| LWK | 84.4 | 15.6 | 0.0
| MEX | 24.6 | 50.9 | 24.6
| MKK | 68.4 | 24.5 | 7.1
| TSI | 29.4 | 52.9 | 17.6
| HapMapRevision=28
}}[http://genes2brains2mentalhealth.wordpress.com/2009/01/06/piccolo-leads-a-long-commute-away-from-major-depressive-disorder/ blog] (C;C) linked to major depressive disorder {{doi|10.1038/mp.2008.125}}

{{PMID Auto
|PMID=19065144
|Title=Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
|OA=1
}}

{{PMID Auto
|PMID=20701824
|Title=PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder
}}

{{PMID Auto
|PMID=6846250
|Title=A phase II study of 6-diazo-5-oxo-L-norleucine (DON, NSC-7365) in advanced large bowel carcinoma.
}}

{{PMID Auto
|PMID=22649524
|Title=A Fine-Mapping Study of 7 Top Scoring Genes from a GWAS for Major Depressive Disorder
|OA=1
}}

{{PMID Auto
|PMID=22293360
|Title=Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protein 1 rs4675690 and Piccolo rs2522833, in a Japanese population
}}

{{PMID Auto
|PMID=22832909
|Title=Piccolo genotype modulates neural correlates of emotion processing but not executive functioning
|OA=1
}}

{{PMID Auto
|PMID=18647954
|Title=PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.
|OA=1
}}

{{PMID Auto
|PMID=19942622
|Title=The PCLO gene and depressive disorders: replication in a population-based study.
}}

{{PMID Auto
|PMID=22386049
|Title=PCLO gene: its role in vulnerability to major depressive disorder.
}}

{{GET Evidence
|gene=PCLO
|aa_change=Ser4814Ala
|aa_change_short=S4814A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2522833
|overall_frequency_n=3151
|overall_frequency_d=9832
|overall_frequency=0.320484
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}