{{Rsnum
|rsid=2523608
|Gene=HLA-B
|Chromosome=6
|position=31354782
|Orientation=minus
|GMAF=0.421
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HLA-B,MIR6891
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 20.4 | 48.7 | 31.0
| HCB | 32.8 | 50.4 | 16.8
| JPT | 11.5 | 47.8 | 40.7
| YRI | 12.2 | 36.7 | 51.0
| ASW | 5.3 | 59.6 | 35.1
| CHB | 32.8 | 50.4 | 16.8
| CHD | 44.0 | 44.0 | 11.9
| GIH | 10.9 | 49.5 | 39.6
| LWK | 10.1 | 38.5 | 51.4
| MEX | 20.7 | 39.7 | 39.7
| MKK | 10.3 | 48.1 | 41.7
| TSI | 11.8 | 42.2 | 46.1
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20205591
|Trait=HIV-1 control
|Title=Host determinants of HIV-1 control in African Americans
|RiskAllele=
|Pval=0.000003
|OR=None
|ORtxt=None
|OA=1
}}

{{PharmGKB
|RSID=rs2523608
|Name_s=
|Gene_s=HLA-B
|Feature=
|Evidence=PubMed ID:16998491
|Annotation=Risk or phenotype-associated allele: allele 4. Phenotype: Combined alleles of rs1058026 (1), rs2523608 (4), and rs2596439 (formerly rs6929932) (4) are tagging SNPs for HLA-B*5801. Study size: 90 (30 trios). Study population/ethnicity: Yorubans from Ibadan, Nigeria. Significance metric(s): Type of association: GN
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165291975
}}

{{PMID Auto GWAS
|PMID=21051598
|Trait=None
|Title=The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
|RiskAllele=G
|Pval=9E-20
|OR=2.6000
|ORtxt=[NR]
|OA=1
}}

{{ClinVar
|rsid=2523608
|Reversed=1
|FwdREF=C
|FwdALT=T
|REF=G
|ALT=A
|RSPOS=31322559
|CHROM=6
|GMAF=0.4217
|dbSNPBuildID=100
|SSR=0
|SAO=0
|VP=0x05016808000117051e120100
|GENEINFO=HLA-B:3106
|GENE_NAME=HLA-B
|GENE_ID=3106
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.31322559G>A
|CLNSIG=7
|Tags=RV;PM;PMC;SLO;INT;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;LSD;MTP
|CAF=0.421; 0.579
|COMMON=1
}}

{{PMID Auto
|PMID=20018067
|Title=A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=22474614
|Title=Host Genes Important to HIV Replication and Evolution.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2523608
|overall_frequency_n=75
|overall_frequency_d=126
|overall_frequency=0.595238
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23417110
  |Trait=Beta-2 microglubulin plasma levels
  |Title=Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.
  |RiskAllele=A
  |Pval=9E-9
  |OR=.02
  |ORtxt=[0.012-0.028] unit increase
  }}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}