{{Rsnum
|rsid=2548861
|Gene=WWOX
|Chromosome=16
|position=78624496
|Orientation=plus
|GMAF=0.4931
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=WWOX
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 38.1 | 43.4 | 18.6
| HCB | 32.8 | 52.6 | 14.6
| JPT | 41.6 | 46.9 | 11.5
| YRI | 7.5 | 39.5 | 53.1
| ASW | 17.5 | 38.6 | 43.9
| CHB | 32.8 | 52.6 | 14.6
| CHD | 38.0 | 43.5 | 18.5
| GIH | 18.8 | 48.5 | 32.7
| LWK | 4.5 | 30.9 | 64.5
| MEX | 31.0 | 46.6 | 22.4
| MKK | 9.0 | 38.5 | 52.6
| TSI | 27.7 | 52.5 | 19.8
| HapMapRevision=28
}}{{PMID|18674750|OA=1
}} 9,798 subjects show significant association between rs2548861(T) and Low serum HDL-cholesterol, a major risk factor for [[coronary artery disease]]. p = 4 x 10(-4) to 2 x 10(-5)

{{PharmGKB
|RSID=rs2548861
|Name_s=
|Gene_s=WWOX
|Feature=
|Evidence=PubMed ID:18674750
|Annotation=In dyslipidemic families of Mexican and European descent and in low-HDL-C cases and controls of European descent, this SNP showed significant association with low HDL-C. In two Finnish cohorts (one was prospective),the same association was significant at four time points taken over 21 years, and the T allele was the risk allele.
|Drugs=
|Drug Classes=
|Diseases=Coronary Artery Disease; Hyperlipidemias
|Curation Level=Curated
|PharmGKB Accession ID=PA162372890
}}

{{PMID Auto
|PMID=19844255
|Title=Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2548861
|overall_frequency_n=63
|overall_frequency_d=126
|overall_frequency=0.5
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=53
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23197378
|Title=Genetic and epigenetic alterations of WWOX in the development of gastric cardia adenocarcinoma
}}

{{PMID Auto
|PMID=22213016
|Title=Decreased expression of WWOX in the development of esophageal squamous cell carcinoma.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}