{{Rsnum
|rsid=25489
|Gene=XRCC1
|Chromosome=19
|position=43552260
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.06061
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=XRCC1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 8.8 | 91.2
| HCB | 0.7 | 18.2 | 81.0
| JPT | 0.9 | 14.2 | 85.0
| YRI | 0.0 | 2.7 | 97.3
| ASW | 0.0 | 5.4 | 94.6
| CHB | 0.7 | 18.2 | 81.0
| CHD | 0.0 | 17.4 | 82.6
| GIH | 1.0 | 17.8 | 81.2
| LWK | 0.0 | 2.7 | 97.3
| MEX | 1.8 | 12.3 | 86.0
| MKK | 0.0 | 7.7 | 92.3
| TSI | 1.0 | 17.6 | 81.4
| HapMapRevision=28
}}
[[rs25489]], a SNP also known as Arg280His located in the DNA-repair gene [[XRCC1]], is associated with an increased risk for [[breast cancer]] based on a study of 1,100 Cypriot women. The odds ratio for the [[rs25489]](A;A) homozygote is 4.68, CI: 1.01-21.7, p=0.03.{{PMID|18188695}}

[[rs25489]](A;G) [[prostate cancer]] patients being treated by radiation therapy are more likely (67% compared to 24%, p=0.048) to develop erectile dysfunction after irradiation than (G;G) patients, based on a study of 135 patients.{{PMID|18582155}}

{{PMID|21216841}} A meta-analysis concludes that this SNP is not associated with risk of gastric cancer.

{{ neighbor
| rsid = 25487
| distance = 686
}}

{{PMID Auto
|PMID=17767850
|Title=Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer: a case-control study
}}

{{PMID Auto
|PMID=19707910
|Title=Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis
}}

{{PMID Auto
|PMID=21419115
|Title=DNA Repair Gene ERCC2 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck
}}

{{PMID|15113441|OA=1
}} Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.

{{PMID|16931584|OA=1
}} Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC1.

{{PMID|17425776|OA=1
}} DNA repair gene XRCC1 polymorphisms and bladder cancer risk.

{{PMID|17984110}} Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.

{{PMID|18191955|OA=1
}} Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.

{{PMID|18298806|OA=1
}} Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.

{{PMID|18544627|OA=1
}} Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.

{{PMID|18547414|OA=1
}} Genotyping panel for assessing response to cancer chemotherapy.

{{PMID|18701435|OA=1
}} Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.

{{PMID|18936436|OA=1
}} Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

{{PMID|18990748|OA=1
}} International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.

{{PMID|19029194|OA=1
}} Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.

{{PMID|19138047|OA=1
}} Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan.

{{PMID|19230024|OA=1
}} Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma.

{{PMID|19274602|OA=1
}} Gene-environment interactions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride.

{{PMID|19367277|OA=1
}} Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.

{{PMID|20442803|OA=1
}} XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study.

{{PMID|21420246|OA=1
}} Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.

{{PMID|21427728|OA=1
}} Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2.

{{PMID|22687647}} Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.

{{GET Evidence
|gene=XRCC1
|aa_change=Arg280His
|aa_change_short=R280H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs25489
|overall_frequency_n=463
|overall_frequency_d=10744
|overall_frequency=0.0430938
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23936089
|Title=Polymorphisms in DNA-Repair Genes in a Cohort of Prostate Cancer Patients from Different Areas in Spain: Heterogeneity between Populations as a Confounding Factor in Association Studies
|OA=1
}}

{{PMID Auto
|PMID=24103542
|Title=High-throughput genotyping system as a robust and useful tool in oncology: Experience from a single institution
}}

{{PMID Auto
|PMID=24500421
|Title=Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis
}}

{{PMID Auto
|PMID=23271134
|Title=Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case-control studies.
}}

{{PMID Auto
|PMID=25130814
|Title=[Association of XRCC1 Genetic Polymorphism with Susceptibility to Non-Hodgkin's Lymphoma]
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}