{{Rsnum
|rsid=2549782
|Gene=ERAP2
|Chromosome=5
|position=96895296
|Orientation=plus
|GMAF=0.4458
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ERAP2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 24.1 | 48.2 | 27.7
| HCB | 14.3 | 47.4 | 38.3
| JPT | 18.9 | 55.9 | 25.2
| YRI | 16.0 | 43.8 | 40.3
| ASW | 14.0 | 45.6 | 40.4
| CHB | 14.3 | 47.4 | 38.3
| CHD | 12.1 | 57.9 | 29.9
| GIH | 18.0 | 50.0 | 32.0
| LWK | 25.7 | 58.7 | 15.6
| MEX | 21.4 | 42.9 | 35.7
| MKK | 33.1 | 49.0 | 17.9
| TSI | 19.8 | 46.5 | 33.7
| HapMapRevision=28
}}

[[rs2549782]] is a SNP in the endoplasmic reticulum aminopeptidase 2 [[ERAP2]] gene.

{{PMID|21569342|OA=1
}} A case-control study of 1103 Chilean maternal-fetal dyads and 1637 unpaired African American samples (836 maternal, 837 fetal) concluded that the fetal minor allele [[rs2549782]](G) was associated with 1.3x increased risk (CI: 1.075-1.619) for [[preeclampsia]] in the African American population (p = 0.009), but not in the Chilean population.

{{PMID Auto
|PMID=19578876
|Title=The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations
|OA=1
}}

{{PMID Auto
|PMID=19433412
|Title=Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.
}}

{{PMID Auto
|PMID=20595269
|Title=Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.
}}

{{PMID Auto
|PMID=20843824
|Title=Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.
}}

{{GET Evidence
|gene=ERAP2
|aa_change=Lys392Asn
|aa_change_short=K392N
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2549782
|overall_frequency_n=5834
|overall_frequency_d=10758
|overall_frequency=0.542294
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=69
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24040622
|Title=A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk
|OA=1
}}

{{PMID Auto
|PMID=22837489
|Title=A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}