{{Rsnum
|rsid=25532
|Gene=SLC6A4
|Chromosome=17
|position=30237152
|Orientation=plus
|GMAF=0.06336
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SLC6A4
}}[[rs25532]] is a SNP in a regulatory region upstream of the serotonin transporter  [[SLC6A4]] gene. The more common allele, [[rs25532]](C), is the higher-expressing allele.

A study of patients with [[obsessive compulsive disorder]] (OCD) concluded that the major allele of [[rs25532]] was a major contributor to the association of a corresponding haplotype with this disorder. {{PMID|18055562}}

{{PharmGKB
|RSID=rs25532
|Name_s=
|Gene_s=SLC6A4
|Feature=
|Evidence=PubMed ID:18055562
|Annotation=This study found that the minor allele of the functional C > T single nucleotide polymorphism, rs25532, located less than 150 nucleotides centromeric of the serotonin transporter-linked polymorphic region indel (known as 5-HTTLPR) significantly decreased luciferase reporter gene expression levels by 15-80%, depending on 5-HTTLPR allele background and cell type.
|Drugs=
|Drug Classes=
|Diseases=Obsessive-Compulsive Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA164920373
}}

{{PMID Auto
|PMID=18444253
|Title=Additional functional variation at the SLC6A4 gene.
|OA=1
}}

{{PMID Auto
|PMID=18824000
|Title=How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.
|OA=1
}}

{{PMID Auto
|PMID=23510579
|Title=Worldwide population variation and haplotype analysis at the serotonin transporter gene SLC6A4 and implications for association studies.
}}

{{PMID Auto
|PMID=23630162
|Title=Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}