{{Rsnum
|rsid=2568958
|Chromosome=1
|position=72299433
|Orientation=plus
|GMAF=0.3007
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 41.6 | 44.2 | 14.2
| HCB | 85.4 | 13.9 | 0.7
| JPT | 88.5 | 10.6 | 0.9
| YRI | 23.1 | 53.7 | 23.1
| ASW | 26.3 | 54.4 | 19.3
| CHB | 85.4 | 13.9 | 0.7
| CHD | 81.7 | 18.3 | 0.0
| GIH | 35.6 | 47.5 | 16.8
| LWK | 29.1 | 47.3 | 23.6
| MEX | 53.4 | 36.2 | 10.3
| MKK | 36.5 | 48.1 | 15.4
| TSI | 38.6 | 48.5 | 12.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=A
|Pval=1E-11
|OR=3.77
|ORtxt=[2.67-4.87] % SD
}}

{{PharmGKB
|RSID=rs2568958
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 1p31.1; Reported Gene(s): NEGR1; Risk Allele: rs2568958-A); (p-value= 0.00000000001).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740152
}}

{{PharmGKB
|RSID=rs2568958
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 1p31.1; Reported Gene(s): NEGR1; Risk Allele: rs2568958-A); (p-value= 0.00000002).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740164
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID Auto
|PMID=19079261
|Title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
|OA=1
}}

{{PMID Auto
|PMID=19478790
|Title=The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=19553259
|Title=Common body mass index-associated variants confer risk of extreme obesity.
|OA=1
}}

{{PMID Auto
|PMID=20127379
|Title=From monogenic to polygenic obesity: recent advances.
|OA=1
}}

{{PMID Auto
|PMID=20520848
|Title=Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=21304891
|Title=A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
|OA=1
}}

{{PMID Auto
|PMID=21750520
|Title=Implication of European-derived adiposity loci in African Americans.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2568958
|overall_frequency_n=80
|overall_frequency_d=124
|overall_frequency=0.645161
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=69
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23563607
  |Trait=Body mass index
  |Title=Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
  |RiskAllele=A
  |Pval=2E-14
  |OR=1.16
  |ORtxt=[NR]
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}