{{Rsnum
|rsid=2569190
|Gene=CD14
|Chromosome=5
|position=140633331
|Orientation=plus
|GMAF=0.4734
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CD14
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.7 | 59.7 | 22.6
| HCB | 20.5 | 59.0 | 20.5
| JPT | 20.0 | 57.5 | 22.5
| YRI | 4.9 | 49.2 | 45.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 20.5 | 59.0 | 20.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs2569190]], also known as C260T, is a SNP in the [[CD14]] gene. 

{{PMID|18727828|OA=1
}} [[rs2569190]](C) (frequency = 39%) increased [[stroke]] risk among smokers (OR = 2.05, 95% CI=1.09-3.86, p=0.03), but not among non-smokers (OR = 0.93, 95% CI=0.62-1.39, p=0.72)

{{PMID|18417506}} [[rs1295685]] and [[rs20541]] were significantly associated with elevated IgE levels in pooled analyses. [[rs2569190]](T;T) and [[rs2569191]](C;C) genotypes associated with lower IgE

A meta-analysis of 7 studies (comprising a total of 1488 patients and 1600 control subjects) found no significant association between [[rs2569190]] and cerebrovascular diseases.{{PMID|19433913}}

{{ neighbor
| rsid = 5744455
| distance = 391
}}

{{PMID Auto
|PMID=19468702
|Title=Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity
|OA=1
}}

{{PMID Auto
|PMID=19701968
|Title=Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection
|OA=1
}}
{{PMID Auto
|PMID=19741468
|Title=Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation
}}
{{PMID Auto
|PMID=19830784
|Title=Association of CD14 variant with prostate cancer in African American men
|OA=1
}}

{{PMID Auto
|PMID=19968655
|Title=The role of lipopolysaccharide in the development of atopy in humans
}}

{{PMID Auto
|PMID=20109750
|Title=Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli
}}

{{PMID Auto
|PMID=22015088
|Title=CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma
}}

{{PMID Auto
|PMID=15726497
|Title=Gene-environment interaction effects on the development of immune responses in the 1st year of life.
|OA=1
}}

{{PMID Auto
|PMID=15867866
|Title=Polymorphisms in the 5' region of the CD14 gene are associated with eczema in young children.
}}

{{PMID Auto
|PMID=16614348
|Title=Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment.
}}

{{PMID Auto
|PMID=16759385
|Title=Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).
|OA=1
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=16846490
|Title=Lemierre's syndrome and genetic polymorphisms: a case report.
|OA=1
}}

{{PMID Auto
|PMID=17062130
|Title=Polymorphisms within inflammatory genes and colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=18987746
|Title=Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19337058
|Title=CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19759553
|Title=Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.
|OA=1
}}

{{PMID Auto
|PMID=20398919
|Title=CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?
}}

{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
|OA=1
}}

{{PMID Auto
|PMID=21320344
|Title=Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
|OA=1
}}

{{PMID Auto
|PMID=21333644
|Title=C(-260)T polymorphism in the promoter of CD 14 gene is not associated with myocardial infarction in the Tunisian population.
}}

{{PMID Auto
|PMID=21389010
|Title=Endotoxin exposure, CD14 and wheeze among farmers: a gene--environment interaction.
}}

{{PMID Auto
|PMID=21596674
|Title=Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.
|OA=1
}}

{{PMID Auto
|PMID=21885391
|Title=Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.
}}

{{PMID Auto
|PMID=21996339
|Title=Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies.
}}

{{PMID Auto
|PMID=22376040
|Title=Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
}}

{{PMID Auto
|PMID=22494793
|Title=Innate immunity gene single nucleotide polymorphisms and otitis media
}}

{{PMID Auto
|PMID=23741383
|Title=CD14 -159 C&gt;T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=23349936
|Title=Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity
|OA=1
}}

{{PMID Auto
|PMID=24028589
|Title=TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk
}}

{{PMID Auto
|PMID=22749237
|Title=Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.
|OA=1
}}

{{PMID Auto
|PMID=23459936
|Title=Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}