{{Rsnum
|rsid=258322
|Gene=CDK10
|Chromosome=16
|position=89689495
|Orientation=minus
|GMAF=0.2677
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CDK10
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 73.5 | 25.7 | 0.9
| HCB | 16.1 | 46.0 | 38.0
| JPT | 13.3 | 47.8 | 38.9
| YRI | 72.1 | 25.2 | 2.7
| ASW | 71.9 | 22.8 | 5.3
| CHB | 16.1 | 46.0 | 38.0
| CHD | 15.6 | 50.5 | 33.9
| GIH | 82.2 | 16.8 | 1.0
| LWK | 56.4 | 40.9 | 2.7
| MEX | 77.6 | 22.4 | 0.0
| MKK | 65.4 | 33.3 | 1.3
| TSI | 93.1 | 6.9 | 0.0
| HapMapRevision=28
}}

{{PMID Auto GWAS
|PMID=18483556
|Trait=Black vs. red hair color
|Title=A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
|RiskAllele=T
|Pval=1.9999999999999999E-23
|OR=0.36
|ORtxt=[0.28-0.44] increase in hair color score
|OA=1
}}

{{PMID Auto GWAS
|PMID=19578364
|Trait=Melanoma
|Title=Genome-wide association study identifies three loci associated with melanoma risk
|RiskAllele=A
|Pval=3E-27
|OR=1.67
|ORtxt=[1.52-1.83]
|OA=1
}}

{{omim
|desc=TYROSINASE; TYR
|id=606933
|rsnum=258322
}}

{{omim
|id=155601
|rsnum=258322
}}

{{omim
|id=601800
|rsnum=258322
}}

{{omim
|id=613099
|rsnum=258322
}}

{{PMID Auto GWAS
|PMID=21983787
|Trait=None
|Title=Genome-wide association study identifies three new melanoma susceptibility loci.
|RiskAllele=A
|Pval=3E-27
|OR=1.7000
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs258322
|overall_frequency_n=106
|overall_frequency_d=128
|overall_frequency=0.828125
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=87
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

This SNP occurs within CDK10, (cyclin-dependent kinase 10). The T variant has been associated with increased risk of [[Melanoma]] (OR=1.67, 95%CI 1.52-1.83) {{PMID|19578364|OA=1
}}, (OR=2.26, 95%CI 1.32–3.88) {{PMID|23393597|OA=1
}}.

==References==
{{PMID|19578364|OA=1
}} Genome-wide association study identifies three loci associated with melanoma risk.

[http://blog.23andme.com/2009/07/06/snpwatch-genetic-variants-near-tumor-suppressor-genes-may-increase-risk-for-brain-and-skin-cancer/ 23andMe blog] [[rs258322]] A (T in dbSNP): OR 1.67 for [[Melanoma]]

{{PMID Auto
|PMID=23393597
|Title=Replication and Predictive Value of SNPs Associated with Melanoma and Pigmentation Traits in a Southern European Case-Control Study
|OA=1
}}

{{PMID Auto
|PMID=19340012
|Title=Genome-wide association study of tanning phenotype in a population of European ancestry.
|OA=1
}}

{{PMID Auto
|PMID=19686382
|Title=Genome-wide associations studies for melanoma and nevi.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}