{{Rsnum
|rsid=2619522
|Gene=DTNBP1
|Chromosome=6
|position=15653418
|Orientation=minus
|GMAF=0.2181
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=DTNBP1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 4.4 | 24.8 | 70.8
| HCB | 0.7 | 15.3 | 83.9
| JPT | 0.9 | 10.6 | 88.5
| YRI | 14.3 | 53.7 | 32.0
| ASW | 17.5 | 49.1 | 33.3
| CHB | 0.7 | 15.3 | 83.9
| CHD | 0.9 | 17.4 | 81.7
| GIH | 6.0 | 28.0 | 66.0
| LWK | 21.8 | 42.7 | 35.5
| MEX | 3.4 | 31.0 | 65.5
| MKK | 23.7 | 52.6 | 23.7
| TSI | 2.9 | 33.3 | 63.7
| HapMapRevision=28
}}[http://genes2brains2mentalhealth.wordpress.com/2007/12/21/i-carry-genetic-risk-for-mental-illness/ g2b2mh blog] In a population of healthy individuals, those that carry common variants (such as [[rs760761]], [[rs1018381]], [[rs2619522]]) located in the dysbindin (DTNBP1) gene, a risk factor for [[schizophrenia]], show minor cognitive impairments such as decreased attentional capacity, worse performance on [[memory]] tasks, and alterations in schizotypal beliefs and experiences.

{{PMID Auto
|PMID=19077176
|Title=Variation in the dysbindin gene and normal cognitive function in three independent population samples
}}
{{PMID Auto
|PMID=19252939
|Title=Dysbindin gene (DTNBP1) and schizophrenia in Korean population
}}

{{omim
|desc=DYSTROBREVIN-BINDING PROTEIN 1; DTNBP1
|id=607145
|rsnum=2619522
}}

{{PMID Auto
|PMID=21130223
|Title=Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability
|OA=1
}}

{{PMID Auto
|PMID=12098102
|Title=Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=12474144
|Title=Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.
|OA=1
}}

{{PMID Auto
|PMID=15290652
|Title=A powerful strategy to account for multiple testing in the context of haplotype analysis.
|OA=1
}}

{{PMID Auto
|PMID=15362017
|Title=Association of the DTNBP1 locus with schizophrenia in a U.S. population.
|OA=1
}}

{{PMID Auto
|PMID=17033966
|Title=Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17074466
|Title=DTNBP1 genotype influences cognitive decline in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17192893
|Title=Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder.
}}

{{PMID Auto
|PMID=17264804
|Title=Dysbindin associated with selective serotonin reuptake inhibitor antidepressant efficacy.
}}

{{PMID Auto
|PMID=17336946
|Title=Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level.
}}

{{PMID Auto
|PMID=17445278
|Title=Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.
|OA=1
}}

{{PMID Auto
|PMID=17888175
|Title=Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17964051
|Title=Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder.
}}

{{PMID Auto
|PMID=18562100
|Title=DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients.
}}

{{PMID Auto
|PMID=18663367
|Title=The dystrobrevin-binding protein 1 gene: features and networks.
|OA=1
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=18804346
|Title=Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19065121
|Title=Dysbindin gene (DTNBP1) in major depression: association with clinical response to selective serotonin reuptake inhibitors.
}}

{{PMID Auto
|PMID=19089808
|Title=Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS).
}}

{{PMID Auto
|PMID=20046352
|Title=Effect of the dysbindin gene on antimanic agents in patients with bipolar I disorder.
|OA=1
}}

{{PMID Auto
|PMID=20822372
|Title=Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: lack of association with clinical phenotypes.
}}

{{PMID Auto
|PMID=21305691
|Title=Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis.
}}

{{PMID Auto
|PMID=22580710
|Title=The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}