{{Rsnum
|rsid=2619538
|Gene=DTNBP1
|Chromosome=6
|position=15664978
|Orientation=plus
|GMAF=0.4013
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=DTNBP1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 17.2 | 37.5 | 45.3
| HCB | 95.6 | 4.4 | 0.0
| JPT | 97.7 | 2.3 | 0.0
| YRI | 11.3 | 43.5 | 45.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 95.6 | 4.4 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{omim
|desc=DYSTROBREVIN-BINDING PROTEIN 1; DTNBP1
|id=607145
|rsnum=2619538
}}

{{PharmGKB
|RSID=rs2619538
|Name_s=
|Gene_s=DTNBP1
|Feature=
|Evidence=PubMed ID:15820225; PubMed ID:17192893; PubMed ID:17555717; PubMed ID:18162312
|Annotation=Several studies showed an associaction of this SNP in DTNBP1 with schizophrenia and other psychotic disorders, including substance-induced psychosis. A study in bipolar samples could not find a major contribution of the variation at the SNP to susceptibility to bipolar disorder.
|Drugs=methamphetamine
|Drug Classes=
|Diseases=Bipolar Disorder; Psychotic Disorders; Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162191364
}}

{{PMID Auto
|PMID=19800201
|Title=The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample
|OA=1
}}

{{PMID Auto
|PMID=16044171
|Title=Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations.
}}

{{PMID Auto
|PMID=17033966
|Title=Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17290445
|Title=Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients.
}}

{{PMID Auto
|PMID=17445278
|Title=Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.
|OA=1
}}

{{PMID Auto
|PMID=17888175
|Title=Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=18663367
|Title=The dystrobrevin-binding protein 1 gene: features and networks.
|OA=1
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=18797396
|Title=Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression.
}}

{{PMID Auto
|PMID=19631276
|Title=Dysbindin modulates brain function during visual processing in children.
}}

{{PMID Auto
|PMID=19884986
|Title=Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=21295953
|Title=Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers.
}}

{{PMID Auto
|PMID=21639861
|Title=Effects of DTNBP1 genotype on brain development in children.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2619538
|overall_frequency_n=60
|overall_frequency_d=128
|overall_frequency=0.46875
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}