{{Rsnum
|rsid=2619539
|Gene=DTNBP1
|Chromosome=6
|position=15620624
|Orientation=plus
|GMAF=0.4945
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=DTNBP1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 21.9 | 45.3 | 32.8
| HCB | 44.4 | 42.2 | 13.3
| JPT | 43.2 | 40.9 | 15.9
| YRI | 6.3 | 47.6 | 46.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 44.4 | 42.2 | 13.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[intelligence]] related

{{PMID Auto
|PMID=19496996
|Title=Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects
}}
{{PMID Auto
|PMID=18804346
|Title=Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
|OA=1
}}

{{PharmGKB
|RSID=rs2619539
|Name_s=
|Gene_s=DTNBP1
|Feature=
|Evidence=PubMed ID:17192893; PubMed ID:17555717; PubMed ID:18162312
|Annotation=Several studies showed an associaction of this SNP in DTNBP1 with schizophrenia and other psychotic disorders, including substance-induced psychosis
|Drugs=methamphetamine
|Drug Classes=
|Diseases=Bipolar Disorder; Psychotic Disorders; Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162191365
}}
{{PMID Auto
|PMID=20598229
|Title=DTNBP1 gene is associated with some symptom factors of schizophrenia in Chinese Han nationality
}}

{{PMID Auto
|PMID=12098102
|Title=Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17033966
|Title=Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=17445278
|Title=Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.
|OA=1
}}

{{PMID Auto
|PMID=17888175
|Title=Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=18663367
|Title=The dystrobrevin-binding protein 1 gene: features and networks.
|OA=1
}}

{{PMID Auto
|PMID=18715757
|Title=Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=19089808
|Title=Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS).
}}

{{PMID Auto
|PMID=19369910
|Title=The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2619539
|overall_frequency_n=81
|overall_frequency_d=126
|overall_frequency=0.642857
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=67
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}