{{Rsnum
|rsid=2651899
|Gene=PRDM16
|Chromosome=1
|position=3167148
|Orientation=minus
|GMAF=0.4995
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PRDM16
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 36.3 | 44.2 | 19.5
| HCB | 29.2 | 57.7 | 13.1
| JPT | 37.2 | 46.0 | 16.8
| YRI | 5.4 | 42.2 | 52.4
| ASW | 7.0 | 33.3 | 59.6
| CHB | 29.2 | 57.7 | 13.1
| CHD | 30.3 | 50.5 | 19.3
| GIH | 28.7 | 43.6 | 27.7
| LWK | 10.9 | 44.5 | 44.5
| MEX | 29.3 | 51.7 | 19.0
| MKK | 18.6 | 48.1 | 33.3
| TSI | 23.5 | 58.8 | 17.6
| HapMapRevision=28
}}[[rs2651899]] is a SNP on ch 1p36.32 in the [[PRDM16]] gene.

A large GWAS study of over 5,000 patients with [[migraines]] and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk increases on its own. The odds ratio for the slightly rarer [[rs2651899]](G) allele was 1.11 (CI: 1.07 - 1.15, p = 3.8 x 10e-9).{{doi|10.1038/ng.856}}

A 2013 study published by the American Headache Society reports significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the Northern Indian population.  {{PMID|24266335}}

{{PMID Auto GWAS
|PMID=21666692
|Trait=None
|Title=Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
|RiskAllele=C
|Pval=4E-9
|OR=1.1100
|ORtxt=[1.07-1.15]
|OA=1
}}

{{PMID Auto
|PMID=22072275
|Title=Genetics of migraine in the age of genome-wide association studies
|OA=1
}}

{{PMID Auto
|PMID=24021092
|Title=PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients
}}

{{PMID Auto
|PMID=23294458
|Title=Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine
}}

{{PMID Auto GWAS
  |PMID=23793025
  |Trait=Migraine
  |Title=Genome-wide meta-analysis identifies new susceptibility loci for migraine.
  |RiskAllele=C
  |Pval=4E-14
  |OR=1.09
  |ORtxt=[1.07-1.11]
  }}

{{PMID|24266335}} Genome-wide-associated variants in migraine susceptibility: a replication study from North India.

{{PMID Auto
|PMID=24674449
|Title=A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}