{{Rsnum
|rsid=2652511
|Gene=SLC6A3
|Chromosome=5
|position=1446274
|Orientation=minus
|GMAF=0.4013
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SLC6A3
}}{{PMID Auto
|PMID=19091889
|Title=Striatal dopamine transporter availability associated with polymorphisms in the dopamine transporter gene SLC6A3
}}

{{PharmGKB
|RSID=rs2652511
|Name_s=
|Gene_s=SLC6A3
|Feature=
|Evidence=PubMed ID:18802919
|Annotation=A study in 243 children with ADHD and their parents suggests a role for the promoter region of the SLC6A3 gene in ADHD susceptibility. In the DSM-IV combined subtype, results showed a preferential transmission of the haplotype A/C/C/C/A derived from five SNPs (rs2550948, rs11564750, rs261759, rs2652511, rs2975223) in 5' region of the SLC6A3 gene.
|Drugs=
|Drug Classes=
|Diseases=Attention Deficit Disorder with Hyperactivity
|Curation Level=Curated
|PharmGKB Accession ID=PA162355586
}}

{{PMID Auto
|PMID=19879111
|Title=Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese
}}

{{PMID|16894395}}The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.

{{PMID|18802919}}A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder.

{{PMID|17044101}}A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children.

{{PMID|16082688}}No support for association between the dopamine transporter (DAT1) gene and ADHD.

{{PMID Auto
|PMID=18553640
|Title=Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD.
}}

{{PMID Auto
|PMID=19196467
|Title=Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder.
|OA=1
}}

{{PMID Auto
|PMID=20445798
|Title=Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.
|OA=1
}}

{{PMID Auto
|PMID=20580759
|Title=Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2652511
|overall_frequency_n=9
|overall_frequency_d=50
|overall_frequency=0.18
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24487615
|Title=Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}