{{Rsnum
|rsid=2660753
|Chromosome=3
|position=87061524
|Orientation=plus
|GMAF=0.2681
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 80.5 | 18.6 | 0.9
| HCB | 47.4 | 44.5 | 8.0
| JPT | 54.0 | 41.6 | 4.4
| YRI | 16.3 | 46.9 | 36.7
| ASW | 31.6 | 43.9 | 24.6
| CHB | 47.4 | 44.5 | 8.0
| CHD | 54.1 | 38.5 | 7.3
| GIH | 59.4 | 35.6 | 5.0
| LWK | 11.8 | 45.5 | 42.7
| MEX | 70.7 | 27.6 | 1.7
| MKK | 13.5 | 50.6 | 35.9
| TSI | 79.4 | 17.6 | 2.9
| HapMapRevision=28
}}[http://cancergenetics.wordpress.com/2008/02/15/prostate-cancer-oldnew-snps-and-decodeprca/ cancer-genetics] these snps influence genetic risk for [[prostate cancer]]

{{PMID|18708398|OA=1
}} rs2660753 showed a per-allele OR, 1.08 (95% confidence interval, 1.00-1.16; P = 0.06)

An initial report {{PMID|18974127|OA=1
}} of an association with between this SNP and risk for [[ovarian cancer]] was not replicated when the same authors expanded the study over 12 studies comprising 4,482 cases (and over 6,000 controls).{{PMID|21415361|OA=1
}}

{{PMID Auto
|PMID=19336566
|Title=Replication of the 10q11 and Xp11 Prostate Cancer Risk Variants: Results from a Utah Pedigree-Based Study.
|OA=1
}}

{{PMID Auto GWAS
|PMID=18264097
|Trait=Prostate cancer
|Title=Multiple newly identified loci associated with prostate cancer susceptibility
|RiskAllele=T
|Pval=2.9999999999999997E-8
|OR=1.18
|ORtxt=[1.06-1.31]
}}

{{PMID Auto
|PMID=21898988
|Title=[Two single nucleotide polymorphisms on chromosome 3 and the risk of prostate cancer in Chinese men]
}}

{{PMID Auto
|PMID=22549899
|Title=Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans
|OA=1
}}

{{PMID Auto
|PMID=22733159
|Title=Analysis of prostate cancer association with four single-nucleotide polymorphisms from genome-wide studies and serum phyto-estrogen concentrations
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=19104501
|Title=Prostate cancer genomics: towards a new understanding.
|OA=1
}}

{{PMID Auto
|PMID=19318432
|Title=Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=19366831
|Title=Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
|OA=1
}}

{{PMID Auto
|PMID=21538423
|Title=Early onset prostate cancer has a significant genetic component.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2660753
|overall_frequency_n=83
|overall_frequency_d=128
|overall_frequency=0.648438
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=74
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}