{{Rsnum
|rsid=2660845
|Gene=LTA4H
|Chromosome=12
|position=96044775
|Orientation=plus
|GMAF=0.3949
|Gene_s=LTA4H
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 55.8 | 35.4 | 8.8
| HCB | 20.4 | 56.9 | 22.6
| JPT | 15.0 | 46.0 | 38.9
| YRI | 40.1 | 42.9 | 17.0
| ASW | 33.3 | 47.4 | 19.3
| CHB | 20.4 | 56.9 | 22.6
| CHD | 21.1 | 45.0 | 33.9
| GIH | 49.5 | 40.6 | 9.9
| LWK | 50.0 | 40.9 | 9.1
| MEX | 24.1 | 51.7 | 24.1
| MKK | 32.1 | 46.2 | 21.8
| TSI | 46.1 | 43.1 | 10.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2660845
|Name_s=LTA4H (rs2660845)
|Gene_s=LTA4H
|Feature=Intron
|Evidence=PubMed ID:16293801
|Annotation=Associations were found between LTC4S (rs730012) and LTA4H (rs2660845) and exacerbation rates in asthma patients treated with montelukast.
|Drugs=montelukast
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA162652702
}}

{{omim
|desc=LEUKOTRIENE A4 HYDROLASE; LTA4H
|id=151570
|rsnum=2660845
}}

{{omim
|id=607948
|rsnum=2660845
}}

{{omim
|id=609888
|rsnum=2660845
}}

{{PMID Auto
|PMID=19077707
|Title=Pharmacogenetics of asthma.
|OA=1
}}

{{PMID Auto
|PMID=19130089
|Title=Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
|OA=1
}}

{{PMID Auto
|PMID=19665766
|Title=Genetics and pharmacogenetics of the leukotriene pathway.
|OA=1
}}

{{PMID Auto
|PMID=21112816
|Title=Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects.
|OA=1
}}

{{PMID Auto
|PMID=21385196
|Title=Influence of leukotriene pathway polymorphisms on clinical responses to montelukast in Japanese patients with asthma.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2660845
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=68
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}