{{Rsnum
|rsid=266729
|Gene=ADIPOQ
|Chromosome=3
|position=186841685
|Orientation=plus
|GMAF=0.2507
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=ADIPOQ
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 49.2 | 41.5 | 9.2
| HCB | 51.1 | 37.8 | 11.1
| JPT | 47.7 | 43.2 | 9.1
| YRI | 85.7 | 12.7 | 1.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 51.1 | 37.8 | 11.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs266729]] is a SNP in the adiponectin [[ADIPOQ]] gene that may help elucidate correlations between obesity and some types of cancer.

Two case-control studies including [[colorectal cancer]] patients and controls were conducted; the first case involving 441 patients and 658 controls, all of [[Ashkenazi]] Jewish ancestry, and the second including 199 patients and 199 matched (sex, age and ethnicity) controls. 

[[rs266729]](G) showed decreased [[colorectal cancer]] risk in both studies; in the first, with an odds ratio of 0.72 (CI:0.55-0.95) and in the second, with an odds ratio of 0.52 (CI: 0.34-0.78). Combining the two studies led to an overall decreased colorectal cancer odds ratio of 0.73 (CI: 0.53-0.99) for this allele.[http://jama.ama-assn.org/cgi/content/full/300/13/1523]

[http://blog.23andme.com/2008/09/30/snpwatch-genetic-link-between-obesity-and-colorectal-cancer/ 23andMe blog] [[obesity]] and [[colorectal cancer]] (G;G) 27% lower odds {{PMID|18827209|OA=1
}} 

{{PMID Auto
|PMID=19264763
|Title=Common variation at the Adiponectin locus is not associated with colorectal cancer risk in the United Kingdom
}}
{{PMID Auto
|PMID=19273568
|Title=Genetic variation in adipokine genes and risk of colorectal cancer
}}
{{PMID Auto
|PMID=19359061
|Title=APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes
}}

{{omim
|desc=ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1; ADIPQTL1
|id=612556
|rsnum=266729
}}

{{PharmGKB
|RSID=rs266729
|Name_s=
|Gene_s=ADIPOQ
|Feature=
|Evidence=PubMed ID:18827209
|Annotation=In two case-control studies this SNP in the 5' UTR of the ADIPOQ gene was associated with decreased colorectal cancer risk.
|Drugs=
|Drug Classes=
|Diseases=Colorectal Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162355886
}}

{{PMID Auto
|PMID=20516205
|Title=Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese
}}
{{PMID Auto
|PMID=20576642
|Title=Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population
}}
{{PMID Auto
|PMID=21208676
|Title=Association of the adiponectin rs266729 C&gt;G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort
}}
{{PMID Auto
|PMID=21248784
|Title=Common variation in the adiponectin gene has an effect on systolic blood pressure
}}

{{PMID Auto
|PMID=21397927
|Title=Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk
|OA=1
}}

{{PMID Auto
|PMID=21619462
|Title=The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer
}}

{{PMID Auto
|PMID=21637408
|Title=A lack of association between adiponectin polymorphisms and coronary artery disease in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=21829206
|Title=Adiponectin gene and risk of colorectal cancer
|OA=1
}}

{{PMID Auto
|PMID=21960694
|Title=Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer
|OA=1
}}

{{PMID Auto
|PMID=16955209
|Title=Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
}}

{{PMID Auto
|PMID=16990411
|Title=Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.
}}

{{PMID Auto
|PMID=17357073
|Title=Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
|OA=1
}}

{{PMID Auto
|PMID=17712123
|Title=Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.
}}

{{PMID Auto
|PMID=18451143
|Title=Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18498634
|Title=The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.
|OA=1
}}

{{PMID Auto
|PMID=18506375
|Title=Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.
}}

{{PMID Auto
|PMID=18523726
|Title=Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.
|OA=1
}}

{{PMID Auto
|PMID=18716158
|Title=Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.
|OA=1
}}

{{PMID Auto
|PMID=18765803
|Title=FOXO3A genotype is strongly associated with human longevity.
|OA=1
}}

{{PMID Auto
|PMID=18776141
|Title=Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
|OA=1
}}

{{PMID Auto
|PMID=19037660
|Title=The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.
|OA=1
}}

{{PMID Auto
|PMID=19056609
|Title=Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy.
|OA=1
}}

{{PMID Auto
|PMID=19074982
|Title=Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.
|OA=1
}}

{{PMID Auto
|PMID=19238139
|Title=ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.
|OA=1
}}

{{PMID Auto
|PMID=19324915
|Title=Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.
}}

{{PMID Auto
|PMID=19360113
|Title=The Role of the PGC1alpha Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy.
|OA=1
}}

{{PMID Auto
|PMID=19593725
|Title=Association of maternally inherited GNAS alleles with African-American male birth weight.
|OA=1
}}

{{PMID Auto
|PMID=20011104
|Title=A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
|OA=1
}}

{{PMID Auto
|PMID=20032495
|Title=Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.
}}

{{PMID Auto
|PMID=20114006
|Title=SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study.
}}

{{PMID Auto
|PMID=20201642
|Title=Associations of polymorphisms in adiponectin and leptin genes with men's longevity.
}}

{{PMID Auto
|PMID=20528971
|Title=Low plasma adiponectin concentration is associated with myocardial infarction in young individuals.
}}

{{PMID Auto
|PMID=20554072
|Title=Gestational diabetes mellitus screening based on the gene chip technique.
}}

{{PMID Auto
|PMID=20580771
|Title=Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis.
}}

{{PMID Auto
|PMID=20667095
|Title=Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20848215
|Title=Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.
}}

{{PMID Auto
|PMID=21054480
|Title=Genetic effects of adiponectin on blood lipids and blood pressure.
}}

{{PMID Auto
|PMID=21073447
|Title=Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients.
}}

{{PMID Auto
|PMID=21219602
|Title=Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.
|OA=1
}}

{{PMID Auto
|PMID=21474811
|Title=Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness.
}}

{{PMID Auto
|PMID=21623778
|Title=Adiponectin in chronic heart failure: influence of diabetes and genetic variants.
}}

{{PMID Auto
|PMID=21638131
|Title=Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.
}}

{{PMID Auto
|PMID=22023374
|Title=Application of back propagation artificial neural network on genetic variants in adiponectin ADIPOQ, peroxisome proliferator-activated receptor-gamma, and retinoid X receptor-alpha genes and type 2 diabetes risk in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=22070425
|Title=Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
}}

{{PMID Auto
|PMID=22386722
|Title=Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.
}}

{{PMID Auto
|PMID=23041553
|Title=Genetic association of adipnectin with type 2 diabetes in Jordanian Arab population
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs266729
|overall_frequency_n=24
|overall_frequency_d=128
|overall_frequency=0.1875
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23143890
|Title=Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis
}}

{{PMID Auto
|PMID=23200411
|Title=ADIPOQ gene polymorphisms and cancer risk: A meta-analysis
}}

{{PMID Auto
|PMID=23590551
|Title=Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=23653335
|Title=AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study
}}

{{PMID Auto
|PMID=23658423
|Title=Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals
}}

{{PMID Auto
|PMID=23740135
|Title=The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk
}}

{{PMID Auto
|PMID=23803590
|Title=Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia
}}

{{PMID Auto
|PMID=23845780
|Title=Association of Adiponectin Promoter Variants With Traits and Clusters of Metabolic Syndrome in Arabs: Family-based study
}}

{{PMID Auto
|PMID=23922565
|Title=Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease
|OA=1
}}

{{PMID Auto
|PMID=24055485
|Title=Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population
}}

{{PMID Auto
|PMID=24414038
|Title=Association of four insulin resistance genes with type 2 diabetes mellitus and hypertension in the Chinese Han population
|OA=1
}}

{{PMID Auto
|PMID=23065236
|Title=The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.
}}

{{PMID Auto
|PMID=23144319
|Title=Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
}}

{{PMID Auto
|PMID=23144325
|Title=P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.
|OA=1
}}

{{PMID Auto
|PMID=23552441
|Title=Association of adiponectin gene polymorphism with birth weight in Korean neonates.
}}

{{PMID Auto
|PMID=25038177
|Title=Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men
}}

{{PMID Auto
|PMID=25074391
|Title=Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents
}}

{{PMID Auto
|PMID=25223469
|Title=Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}