{{Rsnum
|rsid=26722
|Gene=SLC45A2
|Chromosome=5
|position=33963765
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.1552
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SLC45A2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 99.1 | 0.9 | 0.0
| HCB | 35.8 | 51.1 | 13.1
| JPT | 43.8 | 39.3 | 17.0
| YRI | 88.4 | 11.6 | 0.0
| ASW | 91.2 | 8.8 | 0.0
| CHB | 35.8 | 51.1 | 13.1
| CHD | 38.5 | 43.1 | 18.3
| GIH | 65.3 | 29.7 | 5.0
| LWK | 93.6 | 6.4 | 0.0
| MEX | 43.9 | 45.6 | 10.5
| MKK | 79.5 | 19.2 | 1.3
| TSI | 98.0 | 2.0 | 0.0
| HapMapRevision=28
}}
Although the [[rs26722]](T) alllele is relatively rare, at least statistically it seems to be associated with darker eye, hair, and skin color, all other things being equal.{{PMID|15714523}}

{{omim
|desc=PIGMENTATION OF HAIR, SKIN, AND EYES, VARIATION IN
|id=606202
|rsnum=26722
|variant=0007
}}

{{ClinVar
|rsid=26722
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=33963870
|CHROM=5
|GMAF=0.1557
|dbSNPBuildID=76
|SSR=0
|SAO=1
|VP=0x050168000000150517110100
|GENEINFO=SLC45A2:51151
|GENE_NAME=SLC45A2
|GENE_ID=51151
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000005.9:g.33963870C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=606202.0007
|CLNSIG=5
|CLNCUI=C2673584
|CLNDBN=Skin/hair/eye pigmentation, variation in, 5
|Disease=Skin/hair/eye pigmentation
|CLNACC=RCV000004762.1
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8448; 0.1552
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C2673584:227240
|COMMON=1
}}

{{PMID|17999355|OA=1
}} A genomewide association study of skin pigmentation in a South Asian population.

{{PMID|18483556|OA=1
}} A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

{{PMID|18806926}} Association of the SLC45A2 gene with physiological human hair colour variation.

{{PMID|19340012|OA=1
}} Genome-wide association study of tanning phenotype in a population of European ancestry.

{{PMID|19384953|OA=1
}} Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.

{{PMID|20042077|OA=1
}} Genetic determinants of hair and eye colours in the Scottish and Danish populations.

{{GET Evidence
|gene=SLC45A2
|aa_change=Glu272Lys
|aa_change_short=E272K
|impact=benign
|qualified_impact=Low clinical importance, Likely benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs26722
|overall_frequency_n=313
|overall_frequency_d=10758
|overall_frequency=0.0290946
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=1
|n_articles_annotated=1
|qualityscore_case_control=5
|qualityscore_severity=0
|qualityscore_treatability=0
|gene_in_genetests=Y
|in_omim=Y
|pph2_score=0.025
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=0
|autoscore=4
|webscore=N
|n_web_uneval=8
|variant_evidence=0
|clinical_importance=1
|summary_short=Pigmentation allele for black hair in Caucasian population.
}}

{{PMID Auto
|PMID=23100201
|Title=A single-nucleotide polymorphism (SNP) multiplex system: the association of five SNPs with human eye and hair color in the Slovenian population and comparison using a Bayesian network and logistic regression model
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}