{{Rsnum
|rsid=2672598
|Gene=HTRA1
|Chromosome=10
|position=124220682
|Orientation=minus
|GMAF=0.4826
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{PMID|18316707|OA=1
}} 
*[[rs11200638]] 1.7x10-14 (-625G>A)is the most significant associated SNP with a high OR of 7.6 (95%CI: 3.94-14.51) 
*[[rs2672598]] 3.0x10-10 (-487T>C)
*[[rs1049331]] 3.7x10-12 (102C>T, Ala34Ala)
*[[rs2293870]] 3.7x10-12 (108G>T, Gly36Gly) 
*haplotype ACCTT, significantly predisposes to AMD (p= 6.68x10-14)
*[[smoking]] and [[rs800292]] (184G>A, Val62Ile) of CFH.
*The combined OR for disease of smoking and [[rs11200638]] (HTRA1) caused a 15.7 fold increased risk 
*The combined OR for [[rs800292]] and [[rs11200638]] showed a 23.3 fold increased risk
*An extremely high population attributable risk (PAR) of 78% was also found.
{{ neighbor
| rsid = 11200638
| distance = 138
}}
{{ neighbor
| rsid = 1049331
| distance = 588
}}

{{PMID Auto
|PMID=19796758
|Title=Comprehensive Analysis of Complement Factor H and LOC387715/ARMS2/HTRA1 Variants with Respect to Phenotype in Advanced Age-related Macular Degeneration
|OA=1
}}

{{PMID Auto
|PMID=18436811
|Title=Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients.
}}

{{PMID Auto
|PMID=19026761
|Title=Molecular pathology of age-related macular degeneration.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}