{{Rsnum
|rsid=2718812
|Chromosome=3
|position=133680858
|Orientation=minus
|GMAF=0.4807
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 19.1 | 56.4 | 24.5
| HCB | 17.2 | 50.0 | 32.8
| JPT | 21.6 | 43.2 | 35.1
| YRI | 54.8 | 35.6 | 9.6
| ASW | 47.4 | 42.1 | 10.5
| CHB | 17.2 | 50.0 | 32.8
| CHD | 21.3 | 50.9 | 27.8
| GIH | 20.0 | 48.0 | 32.0
| LWK | 55.5 | 37.3 | 7.3
| MEX | 21.8 | 49.1 | 29.1
| MKK | 41.3 | 47.1 | 11.6
| TSI | 21.8 | 49.5 | 28.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19084217
|Trait=Serum markers of iron status
|Title=Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels
|RiskAllele=
|Pval=0.000001
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs2718812
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19084217; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (Initial Sample Size: 459 twin pairs; Replication Sample Size: NR); (Region: 3q22.1; Reported Gene(s): TOPBP1; Risk Allele: rs2718812-?); (p-value= 0.000001).This variant is associated with Serum markers of iron status.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740108
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2718812
|overall_frequency_n=74
|overall_frequency_d=128
|overall_frequency=0.578125
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}