{{Rsnum
|rsid=272893
|Gene=SLC22A4
|Chromosome=5
|position=132327369
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.4146
|Gene_s=LOC553103,SLC22A4
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 11.5 | 52.2 | 36.3
| HCB | 35.3 | 47.8 | 16.9
| JPT | 53.1 | 37.2 | 9.7
| YRI | 3.4 | 35.4 | 61.2
| ASW | 5.3 | 33.3 | 61.4
| CHB | 35.3 | 47.8 | 16.9
| CHD | 29.4 | 52.3 | 18.3
| GIH | 44.6 | 42.6 | 12.9
| LWK | 8.3 | 33.0 | 58.7
| MEX | 6.9 | 51.7 | 41.4
| MKK | 10.9 | 39.1 | 50.0
| TSI | 24.5 | 39.2 | 36.3
| HapMapRevision=28
}}{{PMID|18668679}} [[rs272893]] and [[rs273900]] are associated with [[Crohn's disease]] (OR 2.16; 95% CI 1.21-3.59 and OR 2.40; 95% CI 1.43-4.05)

{{Venter SNP
|rsid=272893
|allele=C
|frequency=0.342
|uid=1103654225921
|type=heterozygous_SNP
|hugo=SLC22A4
|ensembl gene=ENSG00000197208
|ensembl transcript=ENST00000378991
|sift=TOLERATED
|disease=Defects in SLC22A4 may be a cause of rheumatoid arthritis (RA).
}}

{{PMID Auto
|PMID=16796743
|Title=Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.
|OA=1
}}

{{PMID Auto
|PMID=17476680
|Title=Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease.
}}

{{GET Evidence
|gene=SLC22A4
|aa_change=Ile306Thr
|aa_change_short=I306T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs272893
|overall_frequency_n=7079
|overall_frequency_d=10758
|overall_frequency=0.658022
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=70
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.001
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}