{{Rsnum
|rsid=2732552
|Chromosome=11
|position=35063045
|Orientation=minus
|GMAF=0.4449
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.3 | 52.3 | 32.4
| HCB | 7.3 | 35.8 | 56.9
| JPT | 7.1 | 40.7 | 52.2
| YRI | 51.0 | 40.0 | 9.0
| ASW | 33.9 | 48.2 | 17.9
| CHB | 7.3 | 35.8 | 56.9
| CHD | 8.3 | 35.8 | 56.0
| GIH | 5.0 | 46.5 | 48.5
| LWK | 52.4 | 37.1 | 10.5
| MEX | 10.3 | 32.8 | 56.9
| MKK | 34.4 | 50.0 | 15.6
| TSI | 23.8 | 43.6 | 32.7
| HapMapRevision=28
}}Rs2732552, a [[SNP]] located at chr 11p13 is one of several variants associated with systemic [[lupus]] erythematosus (SLE). This snp has an intergenic location between the genes [[CD44]] and [[PDHX]].

The association of rs2732552 with SLE was first suggested in an association study of Caucasian patients. In this study of 431 cases and 2155 controls, the p-value of rs2732552 approached but did not meet the genome-wide significance threshold of 5 x 10^-8. {{PMID|19165918|OA=1
}}.

A follow up study found significant association of rs2732552 with SLE in cohorts of multiple ethnicities. In the Caucasian cohort of 4248 cases and 3818 controls, a p-value of 9.03 x 10^-8 with odds ratio of 0.83 was reported. In the African-American cohort of 1569 cases and 1893 controls, a p-value of 5 x 10^3 with odds ratio of 0.81 was reported. In the Asian cohort of 1328 cases and 1348 controls, a p-value of 4.3 x 10^-4 and odds ratio of 0.8 was reported. A meta analysis using all ethnicities detected a significant p-value for association of 2.36 x 10^13. The caucasian minor allele (T) is reported to confer a 0.8x susceptibility for SLE. The authors hypothesize that rs2732552 resides in a genomic region regulating the expression of CD44. {{PMID|21194677|OA=1
}}

Two previous studies have shown that immune cells from SLE patients express different levels of certain CD44 isoforms. T-cells from SLE patients were shown to be highly overexpressing CD44. {{PMID|17237445}} {{PMID|20213807|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}