{{Rsnum
|rsid=2735839
|Gene=KLK3
|Chromosome=19
|position=50861367
|Orientation=plus
|GMAF=0.2916
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 22.1 | 75.2
| HCB | 16.3 | 45.9 | 37.8
| JPT | 18.6 | 44.2 | 37.2
| YRI | 14.3 | 48.3 | 37.4
| ASW | 8.9 | 41.1 | 50.0
| CHB | 16.3 | 45.9 | 37.8
| CHD | 15.6 | 52.3 | 32.1
| GIH | 7.9 | 42.6 | 49.5
| LWK | 15.5 | 48.2 | 36.4
| MEX | 3.4 | 39.7 | 56.9
| MKK | 17.9 | 48.7 | 33.3
| TSI | 2.0 | 26.7 | 71.3
| HapMapRevision=28
}}

[http://cancergenetics.wordpress.com/2008/02/15/prostate-cancer-oldnew-snps-and-decodeprca/ cancer-genetics] these snps influence genetic risk for [[prostate cancer]]
*the [[haplotype]] [[rs6983267]] [[rs1016343]] [[rs4242384]] 
*[[rs7501939]] 
*[[rs1859962]]
*[[rs2660753]]
*[[rs9364554]]
*[[rs6465657]]
*[[rs10993994]]
*[[rs7931342]]
*[[rs2735839]]
*[[rs5945619]]
*[[rs10993994]]

{{PMID|19366831|OA=1
}} Genotyping 13 SNPs (including this one) in 1,308 Caucasian prostate cancer patients led to the conclusion that while none of the SNP associations were as significant as having a first-degree family history of the disease, they did replicate. And in fact, for [[rs2735839]], the risk estimate varied by family history.

{{GWAS Summary
|SNP=rs2735839
|PubMedID=18264097
|Condition=Prostate cancer
|Gene=KLK3
|Risk Allele=G
|pValue=2.00E-018
|OR=1.2
|95CI=1.10-1.33
}}
{{PMID Auto
|PMID=19336566
|Title=Replication of the 10q11 and Xp11 Prostate Cancer Risk Variants: Results from a Utah Pedigree-Based Study.
|OA=1
}}

{{omim
|desc=PROSTATE CANCER, HEREDITARY, 15; HPC15
|id=611959
|rsnum=2735839
}}
{{PMID Auto
|PMID=19902474
|Title=Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans
}}

{{PharmGKB
|RSID=rs2735839
|Name_s=
|Gene_s=KLK3
|Feature=
|Evidence=PubMed ID:18264097; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple newly identified loci associated with prostate cancer susceptibility (Initial Sample Size: 1,854 cases, 1,894 controls; Replication Sample Size: 3,268 cases, 3,366 controls; Risk Allele: rs2735839-G).
|Drugs=
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356746
}}

{{PMID Auto
|PMID=20460480
|Title=Susceptibility loci associated with prostate cancer progression and mortality
|OA=1
}}

{{PMID Auto
|PMID=21465221
|Title=Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
|OA=1
}}

{{PMID Auto
|PMID=21390317
|Title=Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3
|OA=1
}}

{{PMID Auto
|PMID=22549899
|Title=Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans
|OA=1
}}

{{PMID Auto
|PMID=18708398
|Title=Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.
|OA=1
}}

{{PMID Auto
|PMID=18794092
|Title=Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
|OA=1
}}

{{PMID Auto
|PMID=18974127
|Title=Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19104501
|Title=Prostate cancer genomics: towards a new understanding.
|OA=1
}}

{{PMID Auto
|PMID=19153072
|Title=Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19318432
|Title=Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
|OA=1
}}

{{PMID Auto
|PMID=19318570
|Title=A novel prostate cancer susceptibility locus at 19q13.
|OA=1
}}

{{PMID Auto
|PMID=19434657
|Title=Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
|OA=1
}}

{{PMID Auto
|PMID=19505914
|Title=Two independent prostate cancer risk-associated Loci at 11q13.
|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate cancer risk associated loci in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=19823874
|Title=A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.
|OA=1
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20690139
|Title=Meta-analysis of genome-wide and replication association studies on prostate cancer.
}}

{{PMID Auto
|PMID=21318478
|Title=Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.
|OA=1
}}

{{PMID Auto
|PMID=21367958
|Title=Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality.
|OA=1
}}

{{PMID Auto
|PMID=21538423
|Title=Early onset prostate cancer has a significant genetic component.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2735839
|overall_frequency_n=96
|overall_frequency_d=128
|overall_frequency=0.75
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=84
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Prostate-Specific Antigen]]

{{PMID Auto GWAS
  |PMID=23269536
  |Trait=Prostate-specific antigen levels
  |Title=Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
  |RiskAllele=G
  |Pval=6E-37
  |OR=.19
  |ORtxt=[NR] % higher levels
  }}

{{PMID Auto
|PMID=24411283
|Title=Prostate Cancer (PCa) Risk Variants and Risk of Fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
}}

{{PMID Auto
|PMID=22901566
|Title=Effectiveness of the combined evaluation of KLK3 genetics and free-to-total prostate specific antigen ratio for prostate cancer diagnosis.
}}

{{PMID Auto
|PMID=23543094
|Title=Testing for associations between loci and environmental gradients using latent factor mixed models.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}