{{Rsnum
|rsid=2736098
|Gene=TERT
|Chromosome=5
|position=1293971
|Orientation=plus
|ReferenceAllele=G
|GMAF=0.2126
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TERT
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.8 | 52.3 | 36.9
| HCB | 22.2 | 37.8 | 40.0
| JPT | 4.5 | 40.9 | 54.5
| YRI | 0.0 | 11.1 | 88.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.2 | 37.8 | 40.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
A 2014 study "Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer" of 7,683 European cases and 14,397 controls found the minor allele [[rs2736098]](A) in [[TERT]] (telomerase reverse transcriptase) conferring a protective effect of statistically genome-wide significance (per-allele odds ratio (OR) = 0.80, 95% confidence interval (CI) 0.76-0.85, P = 9.8E-14) against [[Pancreatic cancer]].

For example [PMID 23244087] indicates the A allele might be risk-factor for Asians but protective for Europeans.


{{PMID|19151717}} [http://blog.23andme.com/2009/01/20/snpwatch-one-variation-many-cancers/ 23andMe blog] [[rs2736098]] and [[rs401681]] linked to many [[cancer]]s

{{omim
|id=605462
|desc=BASAL CELL CARCINOMA, MULTIPLE
|rsnum=2736098
}}

{{PMID Auto
|PMID=19773453
|Title=Polymorphisms in telomere maintenance genes and risk of lung cancer
}}

{{omim
|id=613059
|rsnum=2736098
}}

{{PMID Auto
|PMID=21160077
|Title=Genetic correction of PSA values using sequence variants associated with PSA levels
|OA=1
}}

{{PMID Auto
|PMID=21350045
|Title=Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population
}}

{{PMID Auto
|PMID=21820706
|Title=Prostate Cancer Risk Alleles and Their Associations With Other Malignancies
|OA=1
}}

{{PMID Auto
|PMID=22041560
|Title=[The relationship between gene polymorphism of telomerase reverse transcriptase and susceptibility to hepatocellular carcinoma]
}}

{{PMID Auto
|PMID=22495810
|Title=Association of genetic variants of human telomerase with colorectal polyps and colorectal cancer risk
}}

{{PMID Auto
|PMID=17267408
|Title=Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells.
|OA=1
}}

{{PMID Auto
|PMID=18978790
|Title=Lung cancer susceptibility locus at 5p15.33.
|OA=1
}}

{{PMID Auto
|PMID=19774073
|Title=Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs.
|OA=1
}}

{{PMID Auto
|PMID=20802237
|Title=Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.
|OA=1
}}

{{PMID Auto
|PMID=21081471
|Title=Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.
|OA=1
}}

{{PMID Auto
|PMID=22136229
|Title=Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.
|OA=1
}}

{{PMID Auto
|PMID=22228261
|Title=Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population.
}}

{{ClinVar
|rsid=2736098
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=1294086
|CHROM=5
|GMAF=0.2129
|dbSNPBuildID=100
|SSR=0
|SAO=0
|VP=0x050168000000150517110100
|GENEINFO=TERT:7015
|GENE_NAME=TERT
|GENE_ID=7015
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000005.9:g.1294086C>T
|CLNSIG=2
|CLNCUI=613059
|CLNDBN=Dyskeratosis congenita autosomal dominant
|Tags=RV;PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7874; 0.2126
|CLNACC=RCV000032400.1
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK22301:C1851970:127550:1775
|CLNSRC=GeneReviews
|CLNSRCID=NBK22301
|COMMON=1
|Disease=Dyskeratosis congenita autosomal dominant
}}

{{PMID Auto
|PMID=22994782
|Title=TERT rs2736098 Polymorphism and Cancer Risk: Results of a Meta-analysis
}}

{{PMID Auto
|PMID=23244087
|Title=Association of TERT rs2736098 Polymorphism with Cancer Risk: a Meta-analysis
}}

{{PMID Auto
|PMID=23392802
|Title=hTERT rs2736098 genetic variants and susceptibility of hepatocellular carcinoma in the Chinese population: a case-control study
}}

{{PMID Auto
|PMID=23738012
|Title=Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in Chinese Women Nonsmokers
|OA=1
}}

{{PMID Auto
|PMID=23937305
|Title=Validation of association of genetic variants at 10q with prostate-specific antigen (PSA) levels in men at high risk for prostate cancer
}}

{{PMID Auto
|PMID=24171766
|Title=Common low-penetrance risk variants associated with breast cancer in Polish women
}}

{{PMID Auto
|PMID=24260099
|Title=Association between the Telomerase Reverse Transcriptase (TERT) rs2736098 Polymorphism and Cancer Risk: Evidence from a Case-Control Study of Non-Small-Cell Lung Cancer and a Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=23085811
|Title=Tobacco consumption and genetic susceptibility to nasopharyngeal carcinoma (NPC) in Thailand.
}}

{{PMID Auto
|PMID=23159463
|Title=Genetic sequence variants are associated with severity of lower urinary tract symptoms and prostate cancer susceptibility.
}}

{{PMID Auto
|PMID=23246478
|Title=Personalized prostate specific antigen testing using genetic variants may reduce unnecessary prostate biopsies.
|OA=1
}}

{{PMID Auto
|PMID=23535824
|Title=Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.
|OA=1
}}

{{PMID Auto
|PMID=24761905
|Title=Genetic Variations in TERT-CLPTM1L Genes and Risk of Lung Cancer in a Chinese Population
}}

{{PMID Auto
|PMID=24861918
|Title=Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer: a case-control study in northeast Chinese male population
}}

{{PMID Auto
|PMID=25007268
|Title=TERT-CLPTM1L Rs401681 C&gt;T Polymorphism Was Associated with a Decreased Risk of Esophageal Cancer in a Chinese Population
}}

{{PMID Auto
|PMID=25027329
|Title=Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
}}

{{PMID Auto
|PMID=25218484
|Title=Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}