{{Rsnum
|rsid=2736340
|Chromosome=8
|position=11486464
|Orientation=plus
|GMAF=0.3792
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 56.6 | 38.9 | 4.4
| HCB | 6.6 | 32.8 | 60.6
| JPT | 9.9 | 44.1 | 45.9
| YRI | 78.9 | 19.0 | 2.0
| ASW | 75.4 | 22.8 | 1.8
| CHB | 6.6 | 32.8 | 60.6
| CHD | 7.3 | 48.6 | 44.0
| GIH | 49.5 | 38.6 | 11.9
| LWK | 77.3 | 22.7 | 0.0
| MEX | 19.0 | 41.4 | 39.7
| MKK | 73.7 | 25.0 | 1.3
| TSI | 65.7 | 27.5 | 6.9
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19503088
|Trait=Rheumatoid arthritis
|Title=REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
|RiskAllele=A
|Pval=6E-9
|OR=1.19
|ORtxt=[1.13-1.27]
|OA=1
}}

{{PMID Auto
|PMID=19740902
|Title=Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population
}}
{{PMID Auto
|PMID=19644876
|Title=Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome
}}
{{PMID Auto
|PMID=19796918
|Title=Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations
|OA=1
}}

{{PMID Auto
|PMID=20156505
|Title=Role of the C8orf13-BLK region in biopsy-proven giant cell arteritis
}}

{{omim
|id=180300
|rsnum=2736340
}}

{{PMID Auto GWAS
|PMID=21408207
|Trait=None
|Title=Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti-dsDNA Autoantibody Production
|RiskAllele=T
|Pval=3E-7
|OR=1.3800
|ORtxt=[1.23-1.56]
|OA=1
}}

{{PMID Auto GWAS
|PMID=22446961
|Trait=None
|Title=Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
|RiskAllele=T
|Pval=9E-10
|OR=1.5380
|ORtxt=None
}}

{{PMID Auto
|PMID=19838195
|Title=A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=20018022
|Title=Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.
|OA=1
}}

{{PMID Auto
|PMID=20169177
|Title=Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=21765104
|Title=Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2736340
|overall_frequency_n=40
|overall_frequency_d=128
|overall_frequency=0.3125
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23740937
  |Trait=Systemic lupus erythematosus and Systemic sclerosis
  |Title=A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
  |RiskAllele=
  |Pval=1E-8
  |OR=1.22
  |ORtxt=[NR]
  }}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
|OA=1
}}

{{PMID Auto
|PMID=22696686
|Title=Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein.
|OA=1
}}

{{PMID Auto
|PMID=23023776
|Title=European genetic ancestry is associated with a decreased risk of lupus nephritis.
|OA=1
}}

{{PMID Auto
|PMID=23678157
|Title=Integrative analyses for functional mechanisms underlying associations for rheumatoid arthritis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}