{{Rsnum
|rsid=2745557
|Gene=PTGS2
|Chromosome=1
|position=186680089
|Orientation=plus
|GMAF=0.1387
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PTGS2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 23.0 | 76.1
| HCB | 0.0 | 5.1 | 94.9
| JPT | 0.9 | 8.0 | 91.2
| YRI | 2.7 | 28.6 | 68.7
| ASW | 1.8 | 29.8 | 68.4
| CHB | 0.0 | 5.1 | 94.9
| CHD | 0.0 | 4.6 | 95.4
| GIH | 4.0 | 31.7 | 64.4
| LWK | 5.5 | 31.8 | 62.7
| MEX | 3.4 | 19.0 | 77.6
| MKK | 5.1 | 47.4 | 47.4
| TSI | 2.9 | 41.2 | 55.9
| HapMapRevision=28
}}A study of 151 Korean families reported that the [[rs2745557]](A) allele of the [[PTGS2]] gene, also known as cyclooxygenase-2 (Cox-2), was overtransmitted (p<0.01) in [[autism]] spectrum disorders.{{PMID|18579107}}

{{ neighbor
| rsid = 5270
| distance = 497
}}

{{PMID Auto
|PMID=19820421
|Title=The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey
}}

{{PMID Auto
|PMID=21705955
|Title=Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility
}}

{{PMID Auto
|PMID=17609663
|Title=COX2 genetic variation, NSAIDs, and advanced prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18038187
|Title=Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphoma.
}}

{{PMID Auto
|PMID=18085997
|Title=Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.
}}

{{PMID Auto
|PMID=18682823
|Title=Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.
|OA=1
}}

{{PMID Auto
|PMID=18768181
|Title=Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19318492
|Title=Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19437564
|Title=No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19560328
|Title=No association between the PPARG gene and schizophrenia in a British population.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}