{{Rsnum
|rsid=2794520
|Chromosome=1
|position=159709026
|Orientation=plus
|GMAF=0.3687
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 43.4 | 45.1 | 11.5
| HCB | 17.6 | 50.7 | 31.6
| JPT | 10.8 | 38.7 | 50.5
| YRI | 69.4 | 29.9 | 0.7
| ASW | 52.6 | 38.6 | 8.8
| CHB | 17.6 | 50.7 | 31.6
| CHD | 24.5 | 49.1 | 26.4
| GIH | 40.6 | 43.6 | 15.8
| LWK | 68.8 | 28.4 | 2.8
| MEX | 35.7 | 51.8 | 12.5
| MKK | 69.0 | 27.7 | 3.2
| TSI | 54.9 | 32.4 | 12.7
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs2794520
|PubMedID=17903293
|Condition=Select biomarker traits
|Gene=CRP
|Risk Allele=
|pValue=3.00E-008
|OR=NA
|95CI=
|OA=1
}}

{{PMID|17903293|OA=1
}} select biomarker trait being C-reactive protein ([[CRP]]) levels

{{PMID Auto GWAS
|PMID=19060910
|Trait=Other metabolic traits
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|RiskAllele=A
|Pval=3E-22
|OR=0.47
|ORtxt=[0.32-0.62] mmol/l decrease
|OA=1
}}

{{PharmGKB
|RSID=rs2794520
|Name_s=
|Gene_s=CRPP1
|Feature=
|Evidence=PubMed ID:19060910; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (Initial Sample Size: 4,763 individuals; Replication Sample Size: NR); (Region: 1q23.2; Reported Gene(s): CRP; Risk Allele: rs2794520-A); (p-value= 3E-22).This variant is associated with Other metabolic traits.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740282
}}

{{PharmGKB
|RSID=rs2794520
|Name_s=
|Gene_s=CRPP1
|Feature=
|Evidence=PubMed ID:17903293; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project (Initial Sample Size: 1,012 individuals (Framingham); Replication Sample Size: NR). This variant is associated with Select biomarker traits.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356517
}}

{{PharmGKB
|RSID=rs2794520
|Name_s=
|Gene_s=CRPP1
|Feature=
|Evidence=PubMed ID:18439552
|Annotation=In a GWAS of subjects from the PARC study (Pharmacogenomics and Risk of Cardiovascular Disease), this was one of the ten SNPs most strongly associated with plasma C-reactive protein levels.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA162399727
}}

{{PMID Auto GWAS
|PMID=21300955
|Trait=None
|Title=Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
|RiskAllele=C
|Pval=0
|OR=0.1600
|ORtxt=[0.15-0.17] unit increase
|OA=1
}}

{{PMID Auto
|PMID=22230323
|Title=Pharmacogenetic Determinants of Statin-Induced Reductions in C-Reactive Protein
}}

{{PMID Auto
|PMID=17903291
|Title=The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.
|OA=1
}}

{{PMID Auto
|PMID=18216863
|Title=Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
|OA=1
}}

{{PMID Auto
|PMID=18439548
|Title=Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18500540
|Title=Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
|OA=1
}}

{{PMID Auto
|PMID=19426506
|Title=C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2794520
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=43
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23496329
|Title=Genetic variation in C-reactive protein in ethnic Chinese population in Taiwan.
}}

{{PMID Auto
|PMID=24862635
|Title=Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E)
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}