{{Rsnum
|rsid=279845
|Gene=GABRA2
|Chromosome=4
|position=46327706
|Orientation=plus
|GMAF=0.4412
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=GABRA2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 22.1 | 50.4 | 27.4
| HCB | 21.9 | 59.1 | 19.0
| JPT | 23.9 | 44.2 | 31.9
| YRI | 6.1 | 37.4 | 56.5
| ASW | 5.3 | 42.1 | 52.6
| CHB | 21.9 | 59.1 | 19.0
| CHD | 22.2 | 51.9 | 25.9
| GIH | 12.9 | 52.5 | 34.7
| LWK | 7.3 | 42.7 | 50.0
| MEX | 31.0 | 44.8 | 24.1
| MKK | 13.5 | 50.0 | 36.5
| TSI | 13.9 | 43.6 | 42.6
| HapMapRevision=28
}}This SNP in the [[GABRA2]] gene has been linked to [[Alcoholism]].

The strongest association for this SNP is seen when it is a member of a haplotype consisting of the [[rs279871]](A) + [[rs279845]](T) + [[rs279836]](A) alleles {{PMID|15024690|OA=1
}}.

{{omim
|id=137140
|desc=GAMMA-AMINOBUTYRIC ACID RECEPTOR, ALPHA-2; GABRA2
|rsnum=279845
}}

{{omim
|id=137140
|rsnum=279845
|variant=0002
}}

{{PMID Auto
|PMID=22501025
|Title=GABRA2 markers moderate the subjective effects of alcohol
|OA=1
}}

{{PMID|18634760|OA=1
}} Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.

{{PMID|18727688|OA=1
}} The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample.

{{PMID|19487630|OA=1
}} Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring.

{{PMID|20133874|OA=1
}} Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.

{{PMID Auto
|PMID=22555154
|Title=Gamma-aminobutyric acid A receptor, alpha-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}