{{Rsnum
|rsid=279871
|Gene=GABRA2
|Chromosome=4
|position=46303716
|Orientation=minus
|GMAF=0.4123
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GABRA2
}}This SNP in the [[GABRA2]] gene has been linked to [[Alcoholism]].

The strongest association for this SNP is seen when it is a member of a haplotype consisting of the [[rs279871]](A) + [[rs279845]](T) + [[rs279836]](A) alleles {{PMID|15024690|OA=1
}}.

{{omim
|id=137140
|desc=GAMMA-AMINOBUTYRIC ACID RECEPTOR, ALPHA-2; GABRA2
|rsnum=279871
}}

{{PMID Auto
|PMID=20698837
|Title=A Polymorphism in GABRA2 Is Associated With the Medial Frontal Response to Alcohol Cues in an fMRI Study
}}

{{omim
|id=137140
|rsnum=279871
|variant=0001
}}

{{PMID Auto
|PMID=18005236
|Title=Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression.
}}

{{PMID Auto
|PMID=18634760
|Title=Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18727688
|Title=The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample.
|OA=1
}}

{{PMID Auto
|PMID=18781239
|Title=Multiple-domain predictors of problematic alcohol use in young adulthood.
|OA=1
}}

{{PMID Auto
|PMID=19487630
|Title=Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring.
|OA=1
}}

{{PMID Auto
|PMID=19783384
|Title=Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.
|OA=1
}}

{{PMID Auto
|PMID=20133874
|Title=Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.
|OA=1
}}

{{PMID Auto
|PMID=21683760
|Title=Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence.
}}

{{PMID Auto
|PMID=23974430
|Title=Gender-Specific Gene-Environment Interaction in Alcohol Dependence: The Impact of Daily Life Events and GABRA2
}}

{{PMID Auto
|PMID=22817768
|Title=Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}