{{Rsnum
|rsid=2799573
|Chromosome=10
|Orientation=minus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=CACNB2
|position=18601928
|Gene_s=CACNB2
|Assembly=GRCh37.p10
|GenomeBuild=37.5
|dbSNPBuild=138
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 55.8 | 35.4 | 8.8
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 62.4 | 30.7 | 6.9
| LWK | 0.0 | 0.0 | 0.0
| MEX | 44.8 | 48.3 | 6.9
| MKK | 95.5 | 4.5 | 0.0
| TSI | 63.7 | 33.3 | 2.9
| HapMapRevision=28
}}Association between [[rs2799573]] and psychiatric disorders was shown in a 2013 study by the Cross-Disorder Group of the Psychiatric Genomics Consortium {{PMID|23453885}}. In this study, genome-wide SNP data consisting of 1,250,922 autosomal SNPs were analyzed to identify genetic variants associated with [[autism spectrum disorder]], [[ADHD]], [[bipolar disorder]], [[major depressive disorder]], and [[schizophrenia]]. 33,332 cases and 27,888 controls included both unrelated and family-based samples (trios). A multinomial logistic regression procedure was used to identify the best-fitting model of relations between genotype and phenotype. 

This SNP, on chromosome 10 in an intron of [[CACNB2]], was one of four genome-wide significant signals associated with the five psychiatric disorders (p = 4.29 x 10-8). The risk allele T exhibited allele frequency of 0.715 in controls. CACNB2 encodes a voltage-gated calcium-channel subunit that interacts with other calcium-channel subunits to facilitate their function and increase peak calcium current. Although CACNB2 had not been previously identified as a risk gene for schizophrenia and bipolar disorder, its interactor CACNA1C, was known to be a susceptibility gene for bipolar disorder {{PMID|21926972}}, schizophrenia, and major depressive disorder {{PMID|19621016}}. Effects of CACNA1C variants on emotion processing circuitry, attention, and memory were demonstrated in fMRI studies {{PMID|20819988}}{{PMID|21078228}}. Consistent with this, one of the four significant signals from the 2013 study lies within an intron of [[CACNA1C]]. Other peaks identified in this study were [[rs2535629]] and [[rs11191454]].

In addition, a variant within CACNB2 52 kb away from rs2799573 was one of the most significant signals in an independent GWAS of bipolar disorder in Han Chinese{{PMID|20386566}}. All samples analyzed in the Cross-Disorder Group of the Psychiatric Genomics Consortium study were of European ancestry.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}