{{Rsnum
|rsid=2802292
|Gene=FOXO3
|Chromosome=6
|position=108587315
|Orientation=plus
|GMAF=0.449
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=FOXO3
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 20.3 | 45.3 | 34.4
| HCB | 4.4 | 28.9 | 66.7
| JPT | 2.3 | 43.2 | 54.5
| YRI | 68.3 | 30.2 | 1.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 4.4 | 28.9 | 66.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}A study of 5 genes in 3,741 Japanese men, some of whom lived significantly longer than average (centarians), concluded that the [[FOXO3]] gene (also known as FOXO3A) harbors several SNPs linked to [[longevity]], including this SNP, [[rs2802292]], as well as [[rs2764264]] and [[rs13217795]].   
The odds ratio for [[rs2802292]](G;G) vs (T;T) carriers was 2.75 (p = 0.00009; adjusted p = 0.00135). It is not known yet if this correlation is specific to Japanese males.{{PMID|18765803|OA=1
}}

This is discussed extensively at [http://scienceblogs.com/geneticfuture/2008/09/live_long_and_prosper_first_ma.php geneticfuture] as a [[longevity]] snp.
*(T) shorter lifespan
*(G) longer lifespan

Quoted from the geneticfuture article:
"No-one should consider this association to be definitive until it's been replicated in independent cohorts.
Secondly, the effects of this variant are likely to differ between groups. According to the HapMap database the frequency of the "die early" (T) version of the variant varies substantially between populations: it's around 76% in Japanese, slightly more common (81%) in Chinese, less common (58%) in Europeans, and quite rare (17%) in West Africans. Given that the Japanese have the highest life expectancy of any of these populations, this is a counter-intuitive result, which reinforces the fact that there are many genes and other factors influencing variation in longevity."

[http://blog.23andme.com/2009/02/02/snpwatch-mounting-evidence-that-foxo3a-contributes-to-human-longevity/ 23andMe blog] [[longevity]] rs2802288(A) increased the odds of living to 100 by 1.5x. [[rs2802288]] is located very close to [[rs2802292]] which was previously reported to have a similar effect.

A study of males from the Southern Italian Centenarian Study also replicated the association between [[rs2802288]], a proxy of [[rs2802292]], and longevity, with an odds ratio of 1.51 (CI: 1.15-1.98,  p = 0.003).{{PMID|19415983}}

{{omim
|desc=FORKHEAD BOX O3A; FOXO3A
|id=602681
|rsnum=2802292
}}

{{omim
|id=606460
|rsnum=2802292
}}

{{PMID Auto
|PMID=21621268
|Title=Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior
}}

{{PMID Auto
|PMID=19196970
|Title=Association of FOXO3A variation with human longevity confirmed in German centenarians.
|OA=1
}}

{{PMID Auto
|PMID=20881262
|Title=The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins.
}}

{{PMID Auto
|PMID=21115529
|Title=Genetics and genomics of human ageing.
|OA=1
}}

{{PMID Auto
|PMID=24350933
|Title=Association Between Genetic Variations In The Insulin/Insulin-Like Growth Factor (Igf-1) Signaling Pathway And Longevity: A Systematic Review And Meta-Analysis
}}

{{PMID Auto
|PMID=25208626
|Title=Characterization of the rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}