{{Rsnum
|rsid=2808630
|Gene=CRP
|Chromosome=1
|position=159711078
|Orientation=plus
|GMAF=0.2149
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 8.0 | 43.8 | 48.2
| HCB | 5.8 | 26.3 | 67.9
| JPT | 0.9 | 16.8 | 82.3
| YRI | 1.4 | 29.3 | 69.4
| ASW | 0.0 | 26.3 | 73.7
| CHB | 5.8 | 26.3 | 67.9
| CHD | 2.8 | 33.9 | 63.3
| GIH | 6.9 | 43.6 | 49.5
| LWK | 0.0 | 20.2 | 79.8
| MEX | 1.7 | 39.7 | 58.6
| MKK | 1.9 | 15.4 | 82.7
| TSI | 9.9 | 36.6 | 53.5
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs2808630
|PubMedID=18385676
|Condition=Lung cancer
|Gene=CRP
|Risk Allele=G
|pValue=7.00E-006
|OR=1.22
|95CI=1.10-1.35
|OA=1
}}

{{PharmGKB
|RSID=rs2808630
|Name_s=
|Gene_s=CRP, CRPP1
|Feature=Intron, Intron
|Evidence=PubMed ID:18385676; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 (Initial Sample Size: 1,154 cases, 1,137 controls; Replication Sample Size: 2,724 cases, 3,694 controls; Risk Allele: rs2808630-G).
|Drugs=
|Drug Classes=
|Diseases=Lung Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356771
}}

{{PMID Auto
|PMID=19965533
|Title=CRP polymorphisms and progression of chronic kidney disease in African Americans
|OA=1
}}

{{PMID|15897982|OA=1
}} Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

{{PMID|17101857}} Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey.

{{PMID|17888441|OA=1
}} Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.

{{PMID|18167554|OA=1
}} C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

{{PMID|18216863|OA=1
}} Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

{{PMID|18500540|OA=1
}} Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

{{PMID|19267250|OA=1
}} C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

{{PMID|19272152|OA=1
}} IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

{{PMID|19426506|OA=1
}} C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

{{PMID|19639606|OA=1
}} Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

{{PMID|21034294}} C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

{{PMID|21094359}} Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily).

{{PMID|21304900|OA=1
}} Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD.

{{PMID|21979869|OA=1
}} C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

{{PMID Auto
|PMID=23046580
|Title=Association Study of CRP Gene polymorphism and Hypertension in Han Chinese Population
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2808630
|overall_frequency_n=102
|overall_frequency_d=128
|overall_frequency=0.796875
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=87
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23254959
|Title=Serum C-reactive protein and risk of lung cancer: a case-control study
}}

{{PMID Auto
|PMID=23267696
|Title=Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study
|OA=1
}}

{{PMID Auto
|PMID=23496329
|Title=Genetic variation in C-reactive protein in ethnic Chinese population in Taiwan.
}}

{{PMID Auto
|PMID=24894103
|Title=Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}