{{Rsnum
|rsid=2812378
|Gene=CCL21
|Chromosome=9
|position=34710263
|Orientation=minus
|GMAF=0.2801
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CCL21,LOC101929761
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 10.8 | 47.7 | 41.5
| HCB | 0.0 | 14.0 | 86.0
| JPT | 0.0 | 10.1 | 89.9
| YRI | 22.2 | 49.2 | 28.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 14.0 | 86.0
| CHD | 0.0 | 16.8 | 83.2
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 5.2 | 46.1 | 48.7
| TSI | 12.2 | 36.7 | 51.0
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs2812378
|PubMedID=18794853
|Condition=Rheumatoid arthritis
|Gene=CCL21
|Risk Allele=G
|pValue=3.00E-008
|OR=1.12
|95CI=
|OA=1
}}

{{omim
|desc=RHEUMATOID ARTHRITIS; RA
|id=180300
|rsnum=2812378
}}

{{PharmGKB
|RSID=rs2812378
|Name_s=
|Gene_s=CCL21
|Feature=
|Evidence=PubMed ID:18794853; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Common variants at CD40 and other loci confer risk of rheumatoid arthritis (Initial Sample Size: 3,393 cases, 12,460 controls; Replication Sample Size: 3,929 cases, 5,807 controls; Risk Allele: rs2812378-G). This variant is associated with Rheumatoid arthritis.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356417
}}

{{PMID Auto
|PMID=20461788
|Title=Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients
|OA=1
}}

{{PMID|19180477|OA=1
}} Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.

{{PMID|19435719|OA=1
}} Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study.

{{PMID|19674979|OA=1
}} Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

{{PMID|20439292}} Genetic variants in the prediction of rheumatoid arthritis.

{{PMID|20444755|OA=1
}} Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

{{PMID|20797713}} Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.

{{PMID Auto
|PMID=23007924
|Title=Association of Rheumatoid Arthritis Risk Alleles with Response to Anti-TNF Biologics: Results from the CORRONA Registry and Meta-analysis
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2812378
|overall_frequency_n=93
|overall_frequency_d=128
|overall_frequency=0.726562
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=79
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}