{{Rsnum
|rsid=281408
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Chromosome=19
|Orientation=plus
|Gene=RASIP1
|position=48730149
|Gene_s=RASIP1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 17.1 | 49.5 | 33.3
| HCB | 67.2 | 30.7 | 2.2
| JPT | 61.6 | 36.6 | 1.8
| YRI | 6.8 | 39.7 | 53.4
| ASW | 10.5 | 52.6 | 36.8
| CHB | 67.2 | 30.7 | 2.2
| CHD | 78.9 | 18.3 | 2.8
| GIH | 25.7 | 50.5 | 23.8
| LWK | 15.1 | 42.5 | 42.5
| MEX | 29.8 | 56.1 | 14.0
| MKK | 18.8 | 48.7 | 32.5
| TSI | 22.8 | 44.6 | 32.7
| HapMapRevision=28
}}A genome-wide association study of metabolic traits {{PMID|24586186}} found that variations in [[rs28140]]8 are strongly correlated with fucose levels in urine samples, which in turn are associated with [[inflammatory bowel disease]] and [[Crohn’s disease]]. This single nucleotide polymorphism is specifically found in the [[RASIP1]] gene, with reference allele C and minor allele A (P = 9.5x10-27). RASIP1 is positioned within a large linkage-desequilibrium-block on chromosome 19 also encompassing FUT2 and IZUMO1. As such, rs281408 has a strong LD with rs492602 (r2 = 0.87), which is located within the [[FUT2]] gene that encodes for fucosyltransferase. 

FUT2 has previously been associated with vitamin B12 levels in the serum {{PMID|18776911}}. The FUT2 gene product is integral for secretion and display of ABO blood group antigens on mucosal surface cells, which serve as a point of interaction with gut bacteria and pathogenic viruses. Furthermore, fucose levels (the substrate molecule of fucosyl treansferase) have been associated with gut health (by virtue of the microbial composition within) and, by extension, with inflammatory bowel disease and Crohn’s Disease {{PMID|21102463}}. Indeed, Crohn’s Disease mouse models display increased urine fucose levels {{PMID|20141220}}.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}