{{Rsnum
|rsid=2814707
|Chromosome=9
|position=27536399
|Orientation=minus
|GMAF=0.1754
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=LOC102724192
|Gene_s=LOC102724192
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 9.7 | 28.3 | 61.9
| HCB | 0.7 | 9.5 | 89.8
| JPT | 0.0 | 11.5 | 88.5
| YRI | 3.4 | 32.0 | 64.6
| ASW | 5.3 | 28.1 | 66.7
| CHB | 0.7 | 9.5 | 89.8
| CHD | 0.0 | 11.0 | 89.0
| GIH | 1.0 | 24.8 | 74.3
| LWK | 3.6 | 36.4 | 60.0
| MEX | 1.7 | 5.2 | 93.1
| MKK | 3.8 | 34.6 | 61.5
| TSI | 8.8 | 43.1 | 48.0
| HapMapRevision=28
}}[[rs2814707]] is one of 2 SNPs from the ch 9p21.2 region associated in a large GWAS study with [[ALS]] risk, the other SNP being [[rs3849942]]. In this study, the reported odds ratio for [[rs2814707]](A) was 1.22 (CI: 1.15 - 1.30, p = 4.72 x 10e-10).{{PMID|20801717|OA=1
}}

The odds ratio for the minor [[rs2814707]](A) allele was 1.16 (p=7.45x10e-9).{{PMID|19734901}}

[http://blog.23andme.com/2009/09/10/snpwatch-genetic-variations-may-increase-risk-for-als/ 23andMe blog] [[rs2814707]](T) 1.16x odds of [[ALS]]

[[rs12608932]](C) 1.2x odds of [[ALS]]

{{PharmGKB
|RSID=rs2814707
|Name_s=
|Gene_s=MOBKL2B
|Feature=
|Evidence=PubMed ID:18615156
|Annotation=This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.000002; OR: 5.2 (1.8, 16.7)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162928829
}}

{{omim
|id=105550
|rsnum=2814707
}}

{{PMID Auto
|PMID=20423481
|Title=Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
|OA=1
}}

{{PMID Auto
|PMID=20706608
|Title=The role of genetic variation near interferon-kappa in systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=21295378
|Title=Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2814707
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}