{{Rsnum
|rsid=2815752
|Chromosome=1
|position=72346757
|Orientation=minus
|GMAF=0.3007
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 14.2 | 44.2 | 41.6
| HCB | 0.7 | 13.9 | 85.4
| JPT | 0.9 | 10.6 | 88.5
| YRI | 23.1 | 53.7 | 23.1
| ASW | 19.3 | 54.4 | 26.3
| CHB | 0.7 | 13.9 | 85.4
| CHD | 0.0 | 18.3 | 81.7
| GIH | 16.8 | 47.5 | 35.6
| LWK | 23.6 | 47.3 | 29.1
| MEX | 10.3 | 36.2 | 53.4
| MKK | 15.4 | 48.1 | 36.5
| TSI | 12.7 | 49.0 | 38.2
| HapMapRevision=28
}}
{{PMID|19164386|OA=1
}} [[obesity]] and [[type-2 diabetes]]
*[[rs1121980]]
*[[rs7498665]]
*[[rs4752856]]
*[[rs17782313]]
*[[rs2815752]] 
*[[rs10938397]]

{{PMID Auto GWAS
|PMID=19079261
|Trait=Body mass index
|Title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
|RiskAllele=A
|Pval=6E-8
|OR=0.10
|ORtxt=[0.04-0.16] kg/m2 increase
|OA=1
}}

{{PharmGKB
|RSID=rs2815752
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079261; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (Initial Sample Size: 32,387 individuals; Replication Sample Size: 59,092 individuals); (Region: 1p31.1; Reported Gene(s): NEGR1; Risk Allele: rs2815752-A); (p-value= 0.00000006).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740178
}}

{{PMID Auto GWAS
|PMID=20935630
|Trait=None
|Title=Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
|RiskAllele=A
|Pval=2E-22
|OR=0.13
|ORtxt=[0.09-0.17] kg/m2 increase
|OA=1
}}

{{omim
|id=601665
|rsnum=2815752
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=22083549
|Title=Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
}}

{{PMID|19526209|OA=1
}} Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

{{PMID|19553259|OA=1
}} Common body mass index-associated variants confer risk of extreme obesity.

{{PMID|19910938}} Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.

{{PMID|20127379|OA=1
}} From monogenic to polygenic obesity: recent advances.

{{PMID|20144318|OA=1
}} A strategy for analyzing gene-nutrient interactions in type 2 diabetes.

{{PMID|20712903|OA=1
}} Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

{{PMID|21283731|OA=1
}} FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

{{PMID|22179955|OA=1
}} Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2815752
|overall_frequency_n=83
|overall_frequency_d=128
|overall_frequency=0.648438
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=72
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23431394
|Title=Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in chinese han population independently of body mass index
|OA=1
}}

{{PMID Auto
|PMID=23950990
|Title=Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery
|OA=1
}}

{{PMID Auto
|PMID=23471855
|Title=The genetics of childhood obesity and interaction with dietary macronutrients.
|OA=1
}}

{{PMID Auto
|PMID=25072390
|Title=Obesity Gene NEGR1 Associated with White Matter Integrity in Healthy Young Adults
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}