{{Rsnum
|rsid=281865161
|Chromosome=21
|Orientation=minus
|geno1=(GA;GA)
|geno2=(GA;TC)
|geno3=(TC;TC)
|Gene=APP
|position=25897626
|Gene_s=APP
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}{{ClinVar
|ALT=AGA
|CHROM=21
|CLNACC=RCV000019720.26; RCV000034924.1; RCV000084589.1
|CLNALLE=1
|CLNDBN=Alzheimer disease, type 1; Alzheimer's disease; not provided
|CLNDSDB=MedGen; GeneReviews:GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C1863052; NBK1161:NBK1236:C0002395:104300:1020:26929004
|CLNHGVS=NC_000021.8:g.27269938_27269939delTCinsGA
|CLNORIGIN=0
|CLNSIG=5
|CLNSRC=GeneReviews; NCBI; Neurodegenerative Brain Diseases Group; OMIM Allelic Variant
|CLNSRCID=NBK1236; 63750445; ADM_55; 104760.0008; 104760.0018
|Disease=Alzheimer disease; Alzheimer's disease; not provided
|FwdALT=TC
|FwdREF=GA
|REF=ATC
|RSPOS=27269937
|Reversed=1
|SAO=1
|SSR=0
|Tags=RV;PM;PMC;SLO;OTHERKG;LSD;OM
|VC=MNV
|VP=0x050168000000000002110800
|WGT=0
|dbSNPBuildID=137
|rsid=281865161
|GENEINFO=APP:351
|GENE_ID=351
|GENE_NAME=APP
}}{{PMID Auto
|PMID=88
|Title=The oxygen affinity of haemoglobin Tak, a variant with an elongated beta chain.
}}

{{PMID Auto
|PMID=1302033
|Title=A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
}}

{{PMID Auto
|PMID=1465129
|Title=Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
}}

{{PMID Auto
|PMID=7489411
|Title=The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
}}

{{PMID Auto
|PMID=8012386
|Title=Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation.
}}

{{PMID Auto
|PMID=9371838
|Title=Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
|OA=1
}}

{{PMID Auto
|PMID=9796810
|Title=Neuron loss in APP transgenic mice.
}}