{{Rsnum
|rsid=281875280
|Chromosome=9
|position=14776147
|Orientation=minus
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene=FREM1
|Gene_s=FREM1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Orientation=minus
}}{{ClinVar
|ALT=A
|CHROM=9
|CLNACC=RCV000023745.1; RCV000059640.1
|CLNALLE=1
|CLNDBN=Trigonocephaly 2; not provided
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C3280974:614485:3366
|CLNHGVS=NC_000009.11:g.14776145T>A
|CLNSIG=5
|CLNSRC=OMIM Allelic Variant; UniProtKB (variants)
|CLNSRCID=608944.0008; VAR_067917
|Disease=Trigonocephaly 2; not provided
|FwdALT=T
|FwdREF=A
|REF=T
|RSPOS=14776145
|Reversed=1
|SAO=0
|SSR=0
|Tags=RV;PM;PMC;SLO;OTHERKG;LSD
|VC=SNV
|VP=0x050168000000000002100100
|WGT=0
|dbSNPBuildID=137
|rsid=281875280
|GENEINFO=FREM1:158326
|GENE_ID=158326
|GENE_NAME=FREM1
}}{{PMID Auto
|PMID=21931569
|Title=Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
|OA=1
}}