{{Rsnum
|rsid=2820037
|Chromosome=1
|position=239273242
|Orientation=plus
|GMAF=0.1809
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 68.8 | 25.0 | 6.2
| HCB | 86.1 | 13.1 | 0.7
| JPT | 88.5 | 10.6 | 0.9
| YRI | 34.7 | 47.6 | 17.7
| ASW | 52.6 | 35.1 | 12.3
| CHB | 86.1 | 13.1 | 0.7
| CHD | 89.0 | 10.1 | 0.9
| GIH | 75.2 | 20.8 | 4.0
| LWK | 41.8 | 45.5 | 12.7
| MEX | 72.4 | 20.7 | 6.9
| MKK | 40.4 | 39.1 | 20.5
| TSI | 67.6 | 30.4 | 2.0
| HapMapRevision=28
}}
[[rs2820037]] has been reported in a large study to be associated with [[high blood pressure]].

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.54 (CI 1.03-2.31), and for homozygotes, 1.09 (CI 0.74-1.62). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs2820037
|PubMedID=17554300
|Condition=Hypertension
|Gene=RYR2,CHRM3,ZP4
|Risk Allele=T
|pValue=8.00E-007
|OR=1.54
|95CI=1.03-2.31
|OA=1
}}

{{PharmGKB
|RSID=rs2820037
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,952 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs2820037-T). This variant is associated with hypertension.
|Drugs=
|Drug Classes=
|Diseases=Hypertension
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356649
}}

{{PMID|18523456|OA=1
}} Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program.

{{PMID|20018036|OA=1
}} Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2820037
|overall_frequency_n=39
|overall_frequency_d=128
|overall_frequency=0.304688
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23438931
|Title=Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}