{{Rsnum
|rsid=2834167
|Gene=IL10RB
|Chromosome=21
|position=33268483
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3448
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL10RB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 53.1 | 41.6 | 5.3
| HCB | 20.4 | 43.8 | 35.8
| JPT | 25.0 | 52.7 | 22.3
| YRI | 82.3 | 17.0 | 0.7
| ASW | 77.2 | 21.1 | 1.8
| CHB | 20.4 | 43.8 | 35.8
| CHD | 24.8 | 39.4 | 35.8
| GIH | 32.7 | 49.5 | 17.8
| LWK | 86.4 | 11.8 | 1.8
| MEX | 20.7 | 48.3 | 31.0
| MKK | 76.9 | 23.1 | 0.0
| TSI | 58.8 | 32.4 | 8.8
| HapMapRevision=28
}}
[[rs2834167]] is a SNP in the interleukin-10 receptor 2 [[IL10RB]] gene.

In a study of Japanese patients, [[rs2834167]](A;A) individuals were at increased risk for diffuse cutaneous [[systemic sclerosis]] (odds ratio 2.67, p = 0.0018).{{PMID|18588853}}

{{omim
|id=123889
|rsnum=2834167
|variant=0001
}}

{{ClinVar
|rsid=2834167
|Reversed=0
|FwdREF=A
|FwdALT=G
|REF=A
|ALT=G
|RSPOS=34640788
|CHROM=21
|GMAF=0.3457
|dbSNPBuildID=100
|SSR=0
|SAO=1
|VP=0x050378000000150517110101
|GENEINFO=IL10RB:3588
|GENE_NAME=IL10RB
|GENE_ID=3588
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000021.8:g.34640788A>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=123889.0001
|CLNSIG=255
|CLNCUI=C1864880
|CLNDBN=Hepatitis b virus, susceptibility to
|Disease=Hepatitis b virus
|CLNACC=RCV000018431.1
|Tags=PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.6552; 0.3448
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1864880:610424
|COMMON=1
}}

{{PMID Auto
|PMID=19604093
|Title=Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=21532858
|Title=Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population.
|OA=1
}}

{{GET Evidence
|gene=IL10RB
|aa_change=Lys47Glu
|aa_change_short=K47E
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2834167
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23096091
|Title=Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population.
}}

{{PMID Auto
|PMID=23749100
|Title=IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population.
}}

{{PMID Auto
|PMID=25032264
|Title=Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in  Hepatitis B virus-related liver disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}