{{Rsnum
|rsid=28362263
|Gene=PCSK9
|Chromosome=1
|position=55058182
|Orientation=plus
|ReferenceAllele=G
|GMAF=0.02158
|Gene_s=PCSK9
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}[[rs28362263]], also known as A443T, is a SNP in the [[PCSK9]] gene.

It has been reported in several studies (including {{PMID|16912035}} and {{PMID|16465619|OA=1
}}) to be a loss-of-function mutation leading to modestly (~3%) lowered LDL-C levels and thereby somewhat reduced risk for coronary events.

{{PMID Auto
|PMID=20031607
|Title=Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the Coronary Artery Risk Development in Young Adults Study.
|OA=1
}}

{{on chip | HumanOmni1Quad}}