{{Rsnum
|rsid=2836878
|Chromosome=21
|position=39093608
|Orientation=plus
|GMAF=0.2185
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.8 | 39.8 | 51.3
| HCB | 5.1 | 35.8 | 59.1
| JPT | 2.7 | 24.8 | 72.6
| YRI | 1.4 | 9.5 | 89.1
| ASW | 1.8 | 26.3 | 71.9
| CHB | 5.1 | 35.8 | 59.1
| CHD | 2.8 | 33.0 | 64.2
| GIH | 8.9 | 39.6 | 51.5
| LWK | 0.9 | 29.1 | 70.0
| MEX | 3.4 | 55.2 | 41.4
| MKK | 0.0 | 28.2 | 71.8
| TSI | 6.9 | 45.1 | 48.0
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs2836878
|PubMedID=18758464
|Condition=Inflammatory bowel disease
|Gene=PSMG1
|Risk Allele=
|pValue=4.00E-012
|OR=1.41
|95CI=1.08-1.84
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 25; IBD25
|id=612567
|rsnum=2836878
}}

{{PharmGKB
|RSID=rs2836878
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18758464; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease (Initial Sample Size: 1,011 cases, 4,250 controls; Replication Sample Size: 1,922 cases, 14,124 controls). This variant is associated with Inflammatory bowel disease.
|Drugs=
|Drug Classes=
|Diseases=Inflammatory Bowel Diseases
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356553
}}

{{PMID Auto GWAS
|PMID=21300955
|Trait=None
|Title=Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
|RiskAllele=G
|Pval=2E-7
|OR=0.0320
|ORtxt=[0.02-0.04] unit increase
|OA=1
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=G
|Pval=2E-22
|OR=1.2500
|ORtxt=[1.20-1.32]
|OA=1
}}

{{PMID Auto
|PMID=19623168
|Title=Investigation of reported associations between the 20q13 and 21q22 loci and pediatric-onset Crohn's disease in Canadian children.
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2836878
|overall_frequency_n=28
|overall_frequency_d=128
|overall_frequency=0.21875
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=2
|n_articles_annotated=2
|qualityscore_case_control=5
|qualitycomment_case_control=Y
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|summary_short=Associated with Inflammatory bowel disease, Chron's disease. 
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Inflammatory bowel disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=G
  |Pval=5E-48
  |OR=1.18
  |ORtxt=[1.142-1.219]
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}