{{Rsnum
|rsid=28371686
|Gene=CYP2C9
|Chromosome=10
|position=96741058
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.005051
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|Summary=Warfarin (Coumadin®)
|geno1=(G;G)
|geno2=(C;G)
|geno3=(C;C)
}}
{{CPMC SNP
|link=https://cpmc.coriell.org/Sections/Results/Warfarin.aspx?PgId=222
}}
[[rs28371686]], also known as 1080C>G, 42619C>G or D360E, is a SNP in the [[CYP2C9]] gene.

The [[rs28371686]](G) allele defines the CYP2C9*5 variant, which appears to have decreased activity.

{{PMID Auto
|PMID=20214591
|Title=Pharmacogenomics in aspirin intolerance
}}

{{PharmGKB
|RSID=rs28371686
|Name_s=CYP2C9*5;CYP2C9:D360E
|Gene_s=CYP2C9
|Feature=Exon/NonSyn
|Evidence=PubMed ID:20072124
|Annotation=Phenotype: In African Americans patients, weekly warfarin dose requirements were lower in those with the CYP2C9*8 allele (34 (30-47) mg; P = 0.023) and the CYP2C9 *2, *3, *5, *6, or *11 allele (33(28-40 mg); P < 0.001) as compared with those with the CYP2C9*1/*1 genotype (43 (35-56) mg). Adding the *5,*6,*8 and *11 alleles to a model containing the *2 and *3 alleles plus the VKORC1 -1639 G>A allele (along with clinical variables) explained 36% vs. 30% of the variability in dose requirements. Study size: 226 . Study population/ethnicity: African-American . Type of association: PD;GN;CO
|Drugs=warfarin
|Drug Classes=
|Diseases=Atrial Fibrillation; Pulmonary Embolism; Stroke; Venous Thrombosis
|Curation Level=Curated
|PharmGKB Accession ID=PA165260361
}}

{{PMID Auto
|PMID=18466099
|Title=Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.
|OA=1
}}

{{PMID Auto
|PMID=18752379
|Title=Warfarin pharmacogenetics.
|OA=1
}}

{{PMID Auto
|PMID=23133420
|Title=Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}