{{Rsnum
|rsid=28371725
|Gene=CYP2D6
|Chromosome=22
|position=42523805
|Orientation=minus
|GMAF=0.05556
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
[[rs28371725]], also known as 2988G>A, is a SNP in the [[CYP2D6]] gene.

The [[rs28371725]](A) allele defines the CYP2D6*41 variant, which has decreased activity.

23andMe also has SNP [[i4001476]] at the same position.

{{PharmGKB
|RSID=rs28371725
|Name_s=CYP2D6:2988G>A, part of CYP2D6*41
|Gene_s=CYP2D6
|Feature=Intron
|Evidence=PubMed ID:19037197; Web Resource:http://preview.pharmgkb.org/search/annotatedGene/cyp2d6/variant.jsp
|Annotation=This variant is part of the CYP2D6*41 IM haplotype. Plasma concentrations of metoprolol were shown to be were 4.9-fold higher in the PMs, with greater reductions in heart rate, diastolic blood pressure, and mean arterial pressure in PMs than in non-PMs.
|Drugs=metoprolol
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162372821
}}

{{PharmGKB
|RSID=rs28371725
|Name_s=CYP2D6*41; CYP2D6:2988G>A
|Gene_s=CYP2D6
|Feature=Intron
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/cyp2d6/variant.jsp#ImportantVariantInformationforCYP2D6-999
|Annotation=This intronic polymorphism causes a splicing defect resulting in an activity reduction. This variant is diagnostic of the haplotype CYP2D6*41.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161145193
}}

{{PMID Auto
|PMID=22448283
|Title=Genotyping Performance between Saliva and Blood-Derived Genomic DNAs on the DMET Array: A Comparison
|OA=1
}}

{{PMID Auto
|PMID=20174590
|Title=Response to serotonin reuptake inhibitors in OCD is not influenced by common CYP2D6 polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=21071160
|Title=Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs28371725
|overall_frequency_n=846
|overall_frequency_d=10734
|overall_frequency=0.078815
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=5
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}