{{Rsnum
|rsid=28371759
|Gene=CYP3A4
|Chromosome=7
|position=99764003
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.002296
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CYP3A4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 0.0
| HCB | 0.7 | 0.0 | 99.3
| JPT | 0.0 | 2.7 | 97.3
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.7 | 0.0 | 99.3
| CHD | 0.9 | 2.8 | 96.3
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs28371759]], also known as 878T>C, 20070T>C or L293P, is a SNP in the [[CYP3A4]] gene.

The [[rs28371759]](C) allele defines the CYP3A4*18 variant.

{{PharmGKB
|RSID=rs28371759
|Name_s=CYP3A4*18; L293P
|Gene_s=CYP3A4, CYP3A
|Feature=Exon/NonSyn, NA
|Evidence=PubMed ID:19020497
|Annotation=In a study of 2,178 women of ages 40-79 years, this variant in the CYP3A4 gene was significantly associated with low bone mass. In vitro functional analyses indicate that CYP3A4*18 is a gain-of-function mutation in sex steroid metabolism, resulting in rapid oxidation of estrogens and testosterone.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162363873
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}