{{Rsnum
|rsid=2839619
|Gene=PKNOX1
|Chromosome=21
|position=43016067
|Orientation=plus
|GMAF=0.4729
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PKNOX1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 22.1 | 53.1 | 24.8
| HCB | 28.5 | 55.5 | 16.1
| JPT | 20.4 | 49.6 | 30.1
| YRI | 23.8 | 39.5 | 36.7
| ASW | 21.1 | 57.9 | 21.1
| CHB | 28.5 | 55.5 | 16.1
| CHD | 25.7 | 46.8 | 27.5
| GIH | 27.7 | 56.4 | 15.8
| LWK | 31.8 | 54.5 | 13.6
| MEX | 36.2 | 51.7 | 12.1
| MKK | 37.8 | 44.9 | 17.3
| TSI | 41.2 | 38.2 | 20.6
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19260141
|Trait=Biochemical measures
|Title=Genome-wide association study of biochemical traits in Korcula Island, Croatia
|RiskAllele=G
|Pval=0.000008
|OR=0.13
|ORtxt=[0.08-0.18] mmol/L increase
|OA=1
}}{{PMID|19260141|OA=1
}} gwas among adults residing on Korcula Island in Croatia, [[cholesterol]], the G allele associated with increased total cholesterol and increased [[LDL cholesterol]]<br><br>

{{PharmGKB
|RSID=rs2839619
|Name_s=
|Gene_s=PKNOX1
|Feature=
|Evidence=PubMed ID:19260141; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study of biochemical traits in Korcula Island, Croatia. (Initial Sample Size: 898 individuals; Replication Sample Size: NR); (Region: 21q22.3; Reported Gene(s): PKNOX1; Risk Allele: rs2839619-G); (p-value= 0.000008).This variant is associated with Biochemical measures.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740014
}}

{{PharmGKB
|RSID=rs2839619
|Name_s=
|Gene_s=PKNOX1
|Feature=
|Evidence=PubMed ID:19260141; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study of biochemical traits in Korcula Island, Croatia. (Initial Sample Size: 898 individuals; Replication Sample Size: NR); (Region: 21q22.3; Reported Gene(s): PKNOX1; Risk Allele: rs2839619-G); (p-value= 0.000008).This variant is associated with Biochemical measures.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740022
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2839619
|overall_frequency_n=68
|overall_frequency_d=128
|overall_frequency=0.53125
|n_genomes=45
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}