{{Rsnum
|rsid=28416813
|Gene=IL28B
|Chromosome=19
|position=39245004
|Orientation=plus
|GMAF=0.3301
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=IFNL3
}}{{PMID Auto
|PMID=19749757
|Title=Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
}}

{{PharmGKB
|RSID=rs28416813
|Name_s=
|Gene_s=IL28B
|Feature=
|Evidence=PubMed ID:19684573
|Annotation=Phenotype: Sequencing of the IL28B gene in 96 individuals found this SNP to be highly associated with rs12979860 (r - squared > 0.85), which, in a GWAS done in patients of European ancestry, African-Americans and Hispanics was significantly associated with rate of SVR (sustained virological response) to treatment of chronic Hepatitis C genotype I infection with peginterferon-alpha-2a or -2b combined with ribavirin.
|Drugs=interferon alfa-2a, recombinant; ribavirin
|Drug Classes=
|Diseases=Hepatitis; Hepatitis C; Liver Cirrhosis
|Curation Level=Curated
|PharmGKB Accession ID=PA165363368
}}

{{PharmGKB
|RSID=rs28416813
|Name_s=
|Gene_s=IL28B
|Feature=
|Evidence=PubMed ID:19749757
|Annotation=Phenotype: This variant is associated with null virological response (NVR) in Janapese patients with hepatitis C virus infection treated with PEG-INF-alpha plus ribavirin. Study size: 304. Study population/ethnicity: Japanese. Significance metric(s): P=5.5 x 10(-28) (NVR). Type of association: GN; CO
|Drugs=interferon alfa-2a, recombinant; ribavirin
|Drug Classes=
|Diseases=Hepatitis C; Hepatitis C, Chronic
|Curation Level=Curated
|PharmGKB Accession ID=PA165260383
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs28416813
|overall_frequency_n=4095
|overall_frequency_d=10756
|overall_frequency=0.380718
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24116050
|Title=A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}