{{Rsnum
|rsid=2853533
|Gene=TYMS
|Chromosome=18
|position=658064
|Orientation=plus
|GMAF=0.3026
|Gene_s=C18orf56,TYMS
|Assembly=GRCh37.p2
|GenomeBuild=37.2
|dbSNPBuild=134
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 0.0 | 26.2 | 73.8
| HCB | 33.3 | 48.9 | 17.8
| JPT | 22.7 | 50.0 | 27.3
| YRI | 21.7 | 45.0 | 33.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 33.3 | 48.9 | 17.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2853533
|Name_s=TYMS SNP in intron 1; rs2853533G>C
|Gene_s=TYMS, C18orf56
|Feature=
|Evidence=PubMed ID:19683694
|Annotation=Risk or phenotype-associated allele: G Phenotype: The G variant of rs2853533 was associated with Spina Bifida in a transmission disequilibrium test. Study size: 610 families (329 trios, 281 duos) Study population/ethnicity: Patients affected with Spina Bifida and their parents; Houston, TX; Los Angeles, CA; Toronto, ON, Canada Significance metric(s): p = 0.0213 Type of association: CO
|Drugs=
|Drug Classes=
|Diseases=Neural Tube Defects; Spina Bifida Cystica
|Curation Level=Curated
|PharmGKB Accession ID=PA165223220
}}

{{PMID Auto
|PMID=19339911
|Title=Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity.
}}

{{GET Evidence
|gene=C18ORF56
|aa_change=Arg62Gly
|aa_change_short=R62G
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2853533
|overall_frequency_n=2179
|overall_frequency_d=10636
|overall_frequency=0.20487
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=6
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23893618
|Title=Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}